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Title: Stereoselective bioreduction of chalcone and β-diketone by Saccharomyces cerevisiae in biphasic solvent system: A mechanistic study
Authors: Pathan, Naziyanaz B
Rahatgaonkar, Anjali M
Chorghade, Mukund S
Keywords: Stereoselective bioreduction
Saccharomyces cerevisiae
Biphasic-solvent system
Issue Date: Jul-2012
Publisher: NISCAIR-CSIR, India
Abstract:  A mechanistic study of steroselective bio-reduction of chalcones and β-diketones to their corresponding hydroxy derivatives with an effective and versatile biocatalyst i.e. Saccharomyces cerevisiae (Baker’s yeast) in different biphasic solvents systems have been carried out. Maximum bioreduction was observed in pet. ether-water (60% v/v), chloroform-water (60% v/v) for compound (R)-3-(5-chloro-2-hydroxyphenyl)-3-hydroxyl-1-phenylpropane-1-one 2a and (R)-3-(5-methyl-2-hydroxyphenyl)-3-hydroxyl-1-phenylpropane-1-one 2b, respectively while ethanol-water (80%v/v) for 4-chloro-2- ((R, E)-1-hydroxy-3-phenyl allyl) phenol 4a. These biphasic systems are instrumental in integrating bioconversion and product recovery in a single system and shifting the chemical equilibrium to enhance yield and selectivity.
Page(s): 992-1001
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.51B(07) [July 2012]

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