Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/14356
Title: <span style="font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: EN-GB;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" lang="EN-GB">Stereoselective bioreduction of chalcone and β-diketone by <i style="mso-bidi-font-style:normal">Saccharomyces cerevisiae</i> in biphasic solvent system: A mechanistic study</span>
Authors: Pathan, Naziyanaz B
Rahatgaonkar, Anjali M
Chorghade, Mukund S
Keywords: Stereoselective bioreduction
<i><span style="font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: EN-GB;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" lang="EN-GB">Saccharomyces cerevisiae</span></i>
Biphasic-solvent system
Issue Date: Jul-2012
Publisher: NISCAIR-CSIR, India
Abstract: <span style="font-size:12.0pt;font-family: " times="" new="" roman";mso-fareast-font-family:"times="" roman";mso-ansi-language:="" en-gb;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="" lang="EN-GB">&nbsp;A mechanistic study of steroselective bio-reduction of chalcones and β-diketones to their corresponding hydroxy derivatives with an effective and versatile biocatalyst <i style="mso-bidi-font-style: normal">i.e.</i> <i>Saccharomyces cerevisiae</i> (Baker’s yeast) in different biphasic solvents systems have been carried out. Maximum bioreduction was observed in pet. ether-water (60% v/v), chloroform-water (60% v/v) for compound (<i style="mso-bidi-font-style:normal">R</i>)-3-(5-chloro-2-hydroxyphenyl)-3-hydroxyl-1-phenylpropane-1-one <b>2a</b><span style="mso-bidi-font-weight:bold"> and (<i style="mso-bidi-font-style:normal">R</i>)-3-(5-methyl-2-hydroxyphenyl)-3-hydroxyl-1-phenylpropane-1-one<span style="mso-bidi-font-weight:bold"> <b>2b</b>, respectively while ethanol-water (80%v/v) for <span style="mso-bidi-font-weight:bold">4-chloro-2- ((<i style="mso-bidi-font-style:normal">R</i>, <i style="mso-bidi-font-style: normal">E</i>)-1-hydroxy-3-phenyl allyl) phenol <b style="mso-bidi-font-weight: normal">4a</b>. These biphasic systems are instrumental in integrating bioconversion and product recovery in a single system and shifting the chemical equilibrium to enhance yield and selectivity.</span></span></span></span>
Description: 992-1001
URI: http://hdl.handle.net/123456789/14356
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(07) [July 2012]

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