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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.51B [2012] >
IJC-B Vol.51B(07) [July 2012] >
| Title: | Stereoselective bioreduction of chalcone and β-diketone by Saccharomyces cerevisiae in biphasic solvent system: A mechanistic study |
| Authors: | Pathan, Naziyanaz B
Rahatgaonkar, Anjali M
Chorghade, Mukund S |
| Keywords: | Stereoselective bioreduction
Saccharomyces cerevisiae
Biphasic-solvent system |
| Issue Date: | Jul-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A mechanistic study of steroselective
bio-reduction of chalcones and β-diketones to their corresponding hydroxy
derivatives with an effective and versatile biocatalyst i.e. Saccharomyces cerevisiae (Baker’s yeast) in different
biphasic solvents systems have been carried out. Maximum bioreduction was
observed in pet. ether-water (60% v/v), chloroform-water (60% v/v) for compound
(R)-3-(5-chloro-2-hydroxyphenyl)-3-hydroxyl-1-phenylpropane-1-one
2a and (R)-3-(5-methyl-2-hydroxyphenyl)-3-hydroxyl-1-phenylpropane-1-one 2b, respectively while
ethanol-water (80%v/v) for 4-chloro-2-
((R, E)-1-hydroxy-3-phenyl allyl) phenol 4a. These biphasic systems are instrumental in integrating
bioconversion and product recovery in a single system and shifting the chemical
equilibrium to enhance yield and selectivity. |
| Page(s): | 992-1001 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.51B(07) [July 2012]
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