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IJC-B Vol.51B(07) [July 2012] >


Title: Synthesis and anti-inflammatory activity of imidazo[1,2-a] pyridinyl/pyrazinyl benzamides and acetamides
Authors: Hemasrilatha, S
Sruthi, K
Manjula, A
Babu, V Harinadha
Rao, B Vittal
Keywords: Imidazopyridinyl acetamide/benzamide derivatives
Imidazopyrazinyl acetamide/benzamide derivatives
4-arylidene oxazolones
Oedema
Anti-inflammatory activity
Issue Date: Jul-2012
Publisher: NISCAIR-CSIR, India
Abstract: The present study involves synthesis and determination of anti-inflammatory activity of a series of imidazo[1,2-a]pyridinyl/pyrazinyl benzamides and acetamides. Sixteen new imidazo[1,2-a]pyridinyl/pyrazinyl benzamides and acetamides have been prepared by the ring opening of 4-arylidene-2-methyl/phenyloxazolones with 2-amino azaheterocycles. All the compounds show significant anti-inflammatory activity. The anti-inflammatory activity studies reveal that both acetamide and benzamide derivatives are equally active. Among the two classes of compounds, i.e., imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrazines, the latter show better activity.
Page(s): 981-987
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.51B(07) [July 2012]

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