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|Title:||Synthesis and anti-inflammatory activity of imidazo[1,2-a] pyridinyl/pyrazinyl benzamides and acetamides|
Babu, V Harinadha
Rao, B Vittal
|Keywords:||Imidazopyridinyl acetamide/benzamide derivatives;Imidazopyrazinyl acetamide/benzamide derivatives;4-arylidene oxazolones;Oedema;Anti-inflammatory activity|
|Abstract:||The present study involves synthesis and determination of anti-inflammatory activity of a series of imidazo[1,2-a]pyridinyl/pyrazinyl benzamides and acetamides. Sixteen new imidazo[1,2-a]pyridinyl/pyrazinyl benzamides and acetamides have been prepared by the ring opening of 4-arylidene-2-methyl/phenyloxazolones with 2-amino azaheterocycles. All the compounds show significant anti-inflammatory activity. The anti-inflammatory activity studies reveal that both acetamide and benzamide derivatives are equally active. Among the two classes of compounds, i.e., imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrazines, the latter show better activity.|
|Appears in Collections:||IJC-B Vol.51B(07) [July 2012]|
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