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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.51B [2012] >
IJC-B Vol.51B(07) [July 2012] >
| Title: | Synthesis and anti-inflammatory activity of imidazo[1,2-a] pyridinyl/pyrazinyl benzamides and acetamides |
| Authors: | Hemasrilatha, S
Sruthi, K
Manjula, A
Babu, V Harinadha
Rao, B Vittal |
| Keywords: | Imidazopyridinyl acetamide/benzamide derivatives
Imidazopyrazinyl acetamide/benzamide derivatives
4-arylidene oxazolones
Oedema
Anti-inflammatory activity |
| Issue Date: | Jul-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The present study
involves synthesis and determination of anti-inflammatory activity of a series
of imidazo[1,2-a]pyridinyl/pyrazinyl
benzamides and acetamides. Sixteen new
imidazo[1,2-a]pyridinyl/pyrazinyl
benzamides and acetamides have been prepared by the ring opening of
4-arylidene-2-methyl/phenyloxazolones with 2-amino azaheterocycles. All the
compounds show significant anti-inflammatory activity. The anti-inflammatory
activity studies reveal that both acetamide and benzamide derivatives are
equally active. Among the two classes of compounds, i.e., imidazo[1,2-a]pyridine
and imidazo[1,2-a]pyrazines, the
latter show better activity. |
| Page(s): | 981-987 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.51B(07) [July 2012]
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