Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/14354
Title: <span style="font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: EN-GB;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" lang="EN-GB">Synthesis and anti-inflammatory activity of imidazo[1,2-<i style="mso-bidi-font-style:normal">a</i>] pyridinyl/pyrazinyl benzamides and acetamides</span>
Authors: Hemasrilatha, S
Sruthi, K
Manjula, A
Babu, V Harinadha
Rao, B Vittal
Keywords: Imidazopyridinyl acetamide/benzamide derivatives
Imidazopyrazinyl acetamide/benzamide derivatives
4-arylidene oxazolones
Oedema
Anti-inflammatory activity
Issue Date: Jul-2012
Publisher: NISCAIR-CSIR, India
Abstract: <span style="font-size:12.0pt;font-family: " times="" new="" roman";mso-fareast-font-family:"times="" roman";mso-ansi-language:="" en-gb;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="" lang="EN-GB">The present study involves synthesis and determination of anti-inflammatory activity of a series of imidazo[1,2-<i style="mso-bidi-font-style:normal">a</i>]pyridinyl/pyrazinyl benzamides and acetamides. Sixteen<b style="mso-bidi-font-weight:normal"> </b>new imidazo[1,2-<i style="mso-bidi-font-style:normal">a</i>]pyridinyl/pyrazinyl benzamides and acetamides have been prepared by the ring opening of 4-arylidene-2-methyl/phenyloxazolones with 2-amino azaheterocycles. All the compounds show significant anti-inflammatory activity. The anti-inflammatory activity studies reveal that both acetamide and benzamide derivatives are equally active. Among the two classes of compounds, <i style="mso-bidi-font-style: normal">i.e.</i>, imidazo[1,2-<i style="mso-bidi-font-style:normal">a</i>]pyridine and imidazo[1,2-<i style="mso-bidi-font-style:normal">a</i>]pyrazines, the latter show better activity.</span>
Description: 981-987
URI: http://hdl.handle.net/123456789/14354
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(07) [July 2012]

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