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Title: Synthesis of novel α-amino acid functionalized 6-fluoro quinolones, their anti-bacterial activity and molecular docking studies
Authors: Lingaiah, B P Venkat
Yakaiah, T
Shekhar, A Chandra
Kumar, A Ravi
Sathaiah, G
Raju, K
Rao, P Shanthan
Narsaiah, B
Kumar, K Pranay
Murthy, U S N
Purushotham, U
Sastry, G Narahari
Keywords: Quinolones;Aminoacids;Chlorofluoroaniline;Docking studies;Antibacterial
Issue Date: Jul-2012
Publisher: NISCAIR-CSIR, India
Abstract:  A series of novel α-amino acid functionalized 6-fluoro quinolone derivatives have been synthesized from quinoline ester 2 in series of steps with good yields. The compounds have been screened against gram-positive and gram-negative bacteria in-vitro. Some compounds show promising activity against all species of gram-positive and gram-negative bacteria, with reference to standard Norfloxacin as well as Ciprofloxacin. The activity data is validated by molecular docking studies and are in good co-relation with observed trends.
Page(s): 969-980
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(07) [July 2012]

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