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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.51B [2012] >
IJC-B Vol.51B(07) [July 2012] >
| Title: | Synthesis of novel α-amino acid functionalized 6-fluoro quinolones, their anti-bacterial activity and molecular docking studies |
| Authors: | Lingaiah, B P Venkat
Yakaiah, T
Shekhar, A Chandra
Kumar, A Ravi
Sathaiah, G
Raju, K
Rao, P Shanthan
Narsaiah, B
Kumar, K Pranay
Murthy, U S N
Purushotham, U
Sastry, G Narahari |
| Keywords: | Quinolones
Aminoacids
Chlorofluoroaniline
Docking studies
Antibacterial |
| Issue Date: | Jul-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A
series of novel α-amino acid functionalized 6-fluoro quinolone derivatives have
been synthesized from quinoline ester 2 in series of steps with good yields.
The compounds have been screened against gram-positive and gram-negative
bacteria in-vitro. Some compounds
show promising activity against all species of gram-positive and gram-negative
bacteria, with reference to standard Norfloxacin as well as Ciprofloxacin. The
activity data is validated by molecular docking studies and are in good
co-relation with observed trends. |
| Page(s): | 969-980 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.51B(07) [July 2012]
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