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IJC-B Vol.47B(04) [April 2008] >


Title: Synthesis and QSAR studies of thiosemicarbazides, 1,2,4-triazoles, 1,3,4-thiadiazoles and 1,3,4-oxadiazoles derivatives as potential antibacterial agents
Authors: Desai, N C
Bhavsar, A M
Shah, M D
Saxena, Anil K
Keywords: Antibacterial activity
Triazole
Thiadiazole
Oxadiazole
Linear free energy relationship (LFER)
QSAR
Issue Date: Apr-2008
Publisher: CSIR
Abstract: Several new 2-(2-(4-chlorophenyl)acetyl)-N-arylhydrazinecarbothioamides 1, 5-(4-chlorobenzyl)-4-aryl-4H-1,2,4-triazole-3-thiols 2, 5-(4-chlorobenzyl)-N-aryl-1,3,4-thiadiazol-2-amines 3 and 5-(4-chlorobenzyl)-N-aryl-1,3,4-oxadiazol-2-amines 4 have been synthesized and screened for their antibacterial activity against gram +ve and gram –ve bacteria i.e S.aureus and E. coli. The QSAR studies of these compounds have been carried out in terms of structural and physicochemical parameters. Positive contribution of substituents present at position-2 of 2-[2-(4-chlorophenyl)acetyl]-N-arylhydrazine carbothioamides 1 with bulkier group indicate increase in hydrophobicity or steric bulk character.
Page(s): 579-589
ISSN: 0376-4699
Source:IJC-B Vol.47B(04) [April 2008]

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