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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(07) [July 2012] >
| Title: | Anticancer activity of sclerotiorin, isolated from an endophytic fungus Cephalotheca faveolata Yaguchi, Nishim. & Udagawa |
| Authors: | Giridharan, Periyasamy
Verekar, Shilpa Amit
Khanna, Amit
Mishra, P D
Deshmukh, Sunil Kumar |
| Keywords: | Anticancer activity
BAX
BCL-2
Caspase-3
Cephalotheca faveolata
Endophytic fungus
Eugenia jambolana |
| Issue Date: | Jul-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Biodiversity provides critical
support for drug discovery. A significant proportion of drugs are derived,
directly or indirectly, from biological sources. Through high throughput screening (HTS) and
bioassay-guided isolation, bioactive compound sclerotiorin has been isolated from
an endophytic fungus Cephalotheca
faveolata. Sclerotiorin was found to be potent anti-proliferative against
different cancer cells. In this study sclerotiorin has been found to induce
apoptosis in colon cancer (HCT-116) cells through the activation of BAX, and
down-regulation of BCL-2, those further activated cleaved caspase-3 causing
apoptosis of cancer cells. |
| Page(s): | 464-468 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(07) [July 2012]
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