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Title: Anticancer activity of sclerotiorin, isolated from an endophytic fungus Cephalotheca faveolata Yaguchi, Nishim. & Udagawa
Authors: Giridharan, Periyasamy
Verekar, Shilpa Amit
Khanna, Amit
Mishra, P D
Deshmukh, Sunil Kumar
Keywords: Anticancer activity
BAX
BCL-2
Caspase-3
Cephalotheca faveolata
Endophytic fungus
Eugenia jambolana
Issue Date: Jul-2012
Publisher: NISCAIR-CSIR, India
Abstract: Biodiversity provides critical support for drug discovery. A significant proportion of drugs are derived, directly or indirectly, from biological sources. Through high throughput screening (HTS) and bioassay-guided isolation, bioactive compound sclerotiorin has been isolated from an endophytic fungus Cephalotheca faveolata. Sclerotiorin was found to be potent anti-proliferative against different cancer cells. In this study sclerotiorin has been found to induce apoptosis in colon cancer (HCT-116) cells through the activation of BAX, and down-regulation of BCL-2, those further activated cleaved caspase-3 causing apoptosis of cancer cells.
Page(s): 464-468
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.50(07) [July 2012]

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