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Indian Journal of Pure & Applied Physics (IJPAP) >
IJPAP Vol.50 [2012] >
IJPAP Vol.50(07) [July 2012] >
| Title: | Assessment of cell damages induced by gamma rays and pulsed electron beam at different dose rates |
| Authors: | Acharya, A
Joseph, P
Bhat, N N
Sanjeev, G
Narayana, Y |
| Keywords: | Pulsed electron beam
 -rays |
| Issue Date: | Jul-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The analysis of
radiation induced micronuclei frequency in a binucleated cell (MN/BNC) is a
standard biological end point to determine the cell damage as well as absorbed
dose. In the present study, biological end points such as binucleated cells
with micronuclei (BNC with MN) and the number of micronuclei per
micro-nucleated binucleated cell (MN/(BNC with MN)) have been used to assess
the cell damage. Further, the results of BNC with MN and MN/BNC with MN have
been compared with those of previously obtained MN/BNC results. Cell damages
have been assessed in human blood lymphocytes, exposed to 60Co -rays at a dose rate of 0.033 Gy s-1 and 8 MeV pulsed electron beam at a
mean instantaneous dose rate of 2.6  105 Gy s-1. The relative biological
effectiveness (RBE) for electrons in comparison with -rays, has been studied. Dosimeters such as fricke and ferrous
ammonium benzoic acid and xylenol orange have been used for the dose
measurements. The linear-quadratic dose response curves have been observed for
both gamma and electrons. However, the relative effectiveness of 8 MeV
electrons with that of gamma radiation for MN yield was found to be more than
unity for all the biological endpoints studied at a given dose. Present study suggests that the
quantification of BNC with MN and MN/(BNC with MN) along with MN/BNC
provides additional information, while assessing radiation induced cell damage.
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| Page(s): | 474-477 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1041 (Online); 0019-5596 (Print) |
| Source: | IJPAP Vol.50(07) [July 2012]
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