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IJC-B Vol.47B(03) [March 2008] >


Title: Synthesis of some new 5-[2-{(1,2,3-benzotriazole)- 1- yl-methyl}- 1'-(4'-substituted aryl-3'-chloro-2'-oxo azetidine)]-amino-1,3,4- thiadiazoles:Antifungal and antibacterial agents
Authors: Shukla, D K
Srivastava, S D
Keywords: Benzotriazole
Thiadiazoles
Antifungal
Antibacterial
Issue Date: Mar-2008
Publisher: CSIR
Abstract: As a part of systematic investigation of synthesis and biological activity, several new 5-[2-(1,2,3-benzotriazole)-1-yl-methyl]- arylidene hydrazino-1,3,4-thiadiazoles 7 and 5-[2-{(1,2,3-benzotriazole)-1-yl-methyl}-1'- (4'-substituted aryl-3'-chloro-2'-oxo-azetidine]-amino-1,3,4- thiadiazoles 8 have been synthesized from 5-[2-(1,2,3-benzotriazole)-1-yl-methyl]-5- hydrazino-1,3,4-thiadiazoles 6 using 1,2,3-benzotriazole as the starting material. All the synthesized products are evaluated for their antifungal activity against Aspergillus niger, Aspergillus flavus, Fusarium oxisporum and Trichoderma viride and antibacterial activity against Bacilus subtilis, Escherichia coli, Klebsiella pneumoneae and Staphylococcus aureus. The structure of all the synthesized compounds have been determined by spectral and chemical methods.
Page(s): 463-469
ISSN: 0376-4699
Source:IJC-B Vol.47B(03) [March 2008]

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