24-May-2013
10:57:05 IST
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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
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Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.47B [2008] >
IJC-B Vol.47B(03) [March 2008] >
| Title: | Synthesis of some new 5-[2-{(1,2,3-benzotriazole)- 1- yl-methyl}- 1'-(4'-substituted aryl-3'-chloro-2'-oxo azetidine)]-amino-1,3,4- thiadiazoles:Antifungal and antibacterial agents |
| Authors: | Shukla, D K
Srivastava, S D |
| Keywords: | Benzotriazole
Thiadiazoles
Antifungal
Antibacterial |
| Issue Date: | Mar-2008 |
| Publisher: | CSIR |
| Abstract: | As a part of systematic investigation of synthesis and biological activity, several new 5-[2-(1,2,3-benzotriazole)-1-yl-methyl]- arylidene hydrazino-1,3,4-thiadiazoles 7 and 5-[2-{(1,2,3-benzotriazole)-1-yl-methyl}-1'- (4'-substituted aryl-3'-chloro-2'-oxo-azetidine]-amino-1,3,4- thiadiazoles 8 have been synthesized from 5-[2-(1,2,3-benzotriazole)-1-yl-methyl]-5- hydrazino-1,3,4-thiadiazoles 6 using 1,2,3-benzotriazole as the starting material. All the synthesized products are evaluated for their antifungal activity against Aspergillus niger, Aspergillus flavus, Fusarium oxisporum and Trichoderma viride and antibacterial activity against Bacilus subtilis, Escherichia coli, Klebsiella pneumoneae and Staphylococcus aureus. The structure of all the synthesized compounds have been determined by spectral and chemical methods. |
| Page(s): | 463-469 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.47B(03) [March 2008]
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