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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.49 [2012] >
IJBB Vol.49(3) [June 2012] >
| Title: | 6 Paths of ERK5 signaling pathway regulate hepatocyte proliferation in rat liver regeneration |
| Authors: | Li, Zhanpeng
Cheng, Zhenchao
Wang, Gaiping
Hao, Xioxia
Zhang, Lijun
Xu, Cunshuan |
| Keywords: | ERK5 signaling pathway
Rat liver regeneration
Hepatocyte proliferation
Rat genome 230 2.0 array
Gene expression profiles |
| Issue Date: | Jun-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Generally, extra-cellular-signal-regulated
kinase 5 (ERK5) signaling pathway regulates many physiological activities, such
as cell proliferation and cell differentiation. However, little is known about
how ERK5 signaling pathway composed of 15 paths participates in regulating
hepatocyte proliferation during liver regeneration (LR). In this study, to explore
the influence ERK5 signaling pathway upon hepatocytes at gene transcription
level, rat genome 230 2.0 array was used to detect expression changes of 75
related genes in isolated hepatocytes from rat regenerating liver.
Bioinformatics and systems biology methods were applied to analyze the precise
role of ERK5 signaling pathway in regulating hepatocyte proliferation during
LR. Results showed that 62 genes were contained in the array and 22 genes were
significantly changed. It was found that 6 paths were related to hepatocyte
proliferation during rat LR. Among them, paths 3, 6 and 13 of ERK5 signaling
pathway modulated cell cycle progression by decreasing the negative influence
on ERK5 and paths 3, 4, 8 and 9 by reinforcing the positive influence on ERK5. In
summary, the study shows that 22 genes and 6 paths of ERK5
signaling pathway participate in regulating proliferation of hepatocytes in rat
LR. |
| Page(s): | 165-172 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.49(3) [June 2012]
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