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Title: Synthesis and antiulcer activity study of disubstituted alkyl 4-(substituted)-2,6-dimethyl-1-((4-oxo-3-(4-sulfamoylphenyl)-2-thioxo-3,4-dihydroquinazolin-1(2H)-yl) methyl)-1,4-dihydropyridine-3,5 dicarboxylate
Authors: Subudhi, B B
Panda, S K
Ghosh, G
Panda, P K
Keywords: Quinazolinone;Sulfanilamide;1,4-dihydropyridines;Antiulcer activity
Issue Date: Jun-2012
Publisher: NISCAIR-CSIR, India
Abstract: A 2-amino-N-(4-sulfamoyl phenyl) benzamide 1 has been prepared by reaction of anthranilic acid with sulfanilamide. Compound 1 with carbon disulphide furnish 4-(4-oxo-2-thioxo-1, 2-dihydroquinazolin-3(4H)-yl) benzene sulfonamide 2. The compound 2 on reaction with para formaldehyde and 1,4-dihydropyridine derivatives yields disubstituted alkyl 4-(substituted)-2,6-dimethyl-1-((4-oxo-3-(4-sulfamoylphenyl)-2-thi­o­xo-3,4-dihydroquinazolin-1(2H)-yl) methyl)-1,4-dihydro­pyri­dine-3,5 dicarboxylate 3a-h. Antiulcer activities of compounds 3a-h have been evaluated by estimating volume of gastric juice, total acidity, free acidity and ulcer index. Conjunction of 1,4-dihydropyridines with sulfanilamide and quinazolinone results in compounds with antiulcer activity comparable to that of ranitidine. Compounds substituted with methoxy and nitro groups exhibit maximum enhancement in activity.
Page(s): 899-903
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(06) [June 2012]

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