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Title: Synthesis, characterization and microbial assay of new pyridoquinolone-3-carboxamides
Authors: Patel, Navin B
Pathak, Kunal K
Patel, Jignesh N
Modi, Sandip H
Keywords: Antimicrobial activity
Issue Date: Jun-2012
Publisher: NISCAIR-CSIR, India
Abstract: The ethyl pyrido[2,3-h]quinolone carboxamides <b style="">7-31 </b>have been synthesized and their ability to inhibit Gram positive strains <i style="">B. subtilis </i>and<i style=""> S. aureus</i> and Gram negative strains <i style="">E. coli </i>and<i style=""> P. aeruginosa</i> have been tested. Only carboxamides with piperazine derivatives attached at C-3 position show good antibacterial potency compared to standard ciprofloxacin and gatifloxacin. Piperazine derivatives attached at C-3 position of <i>N</i>-ethyl pyrido quinolone increase the activity of their parent compound acid <b style="">6</b>, whereas aryl urea attached at this position decrease the antibacterial activity.
Description: 880-890
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(06) [June 2012]

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