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IJC-B Vol.51B [2012] >
IJC-B Vol.51B(06) [June 2012] >


Title: Synthesis, characterization and microbial assay of new pyridoquinolone-3-carboxamides
Authors: Patel, Navin B
Pathak, Kunal K
Patel, Jignesh N
Modi, Sandip H
Keywords: Antimicrobial activity
Pyridoquinolone
Urea
Piperazine
Issue Date: Jun-2012
Publisher: NISCAIR-CSIR, India
Abstract: The ethyl pyrido[2,3-h]quinolone carboxamides 7-31 have been synthesized and their ability to inhibit Gram positive strains B. subtilis and S. aureus and Gram negative strains E. coli and P. aeruginosa have been tested. Only carboxamides with piperazine derivatives attached at C-3 position show good antibacterial potency compared to standard ciprofloxacin and gatifloxacin. Piperazine derivatives attached at C-3 position of N-ethyl pyrido quinolone increase the activity of their parent compound acid 6, whereas aryl urea attached at this position decrease the antibacterial activity.
Page(s): 880-890
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.51B(06) [June 2012]

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