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Title: L-Proline as an efficient catalyst for synthesis of N-heterocyclic chalcones as potential antibacterial agents
Authors: Bhupathi, Raja S
Devi, B Rama
Dubey, P K
Keywords: L-Proline
Issue Date: Jun-2012
Publisher: NISCAIR-CSIR, India
Abstract: The condensation of 4-hydroxy-3-acetyl-1<i style="">H</i>-quinoline-2-one <b style="">1</b> and substitutedbenzaldehydes <b style="">2a-i</b> in DMSO solution at room temperature yields quinolone chalcone derivatives <b style="">3a-i</b>. l-Proline has been found to be an efficient catalyst for this condensation between <b style="">1</b> and <b style="">2</b>. Only 5 mol% of the catalyst is necessary to achieve good yields of the products. Reactions proceed smoothly with variations of the substituents. <b style="">1 </b>itself is synthesized by the acylation of commercially available methyl anthranilate <b style="">4</b> with acetoacetic ester <b style="">5</b> in refluxing xylene and subsequent Dieckman intramolcular cyclization of the intermediary 2-methoxycarbonylanilide <b style="">6</b>.
Description: 855-859
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(06) [June 2012]

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