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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.51B [2012] >
IJC-B Vol.51B(06) [June 2012] >
| Title: | L-Proline as an efficient catalyst for synthesis of N-heterocyclic chalcones as potential antibacterial agents |
| Authors: | Bhupathi, Raja S
Devi, B Rama
Dubey, P K |
| Keywords: | L-Proline
2-quinolones
Chalcones
Antibacterial
Methylanthranilate |
| Issue Date: | Jun-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The condensation of 4-hydroxy-3-acetyl-1H-quinoline-2-one 1 and substitutedbenzaldehydes 2a-i
in DMSO solution at room temperature yields quinolone chalcone derivatives 3a-i. l-Proline
has been found to be an efficient catalyst for this condensation between 1 and 2. Only 5 mol% of the catalyst is necessary to achieve good yields
of the products. Reactions proceed smoothly with variations of the
substituents. 1 itself is
synthesized by the acylation of commercially available methyl anthranilate 4 with acetoacetic ester 5 in refluxing xylene and subsequent
Dieckman intramolcular cyclization of the intermediary 2-methoxycarbonylanilide
6. |
| Page(s): | 855-859 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.51B(06) [June 2012]
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