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http://nopr.niscair.res.in/handle/123456789/14232
Title: | L-Proline as an efficient catalyst for synthesis of N-heterocyclic chalcones as potential antibacterial agents |
Authors: | Bhupathi, Raja S Devi, B Rama Dubey, P K |
Keywords: | L-Proline;2-quinolones;Chalcones;Antibacterial;Methylanthranilate |
Issue Date: | Jun-2012 |
Publisher: | NISCAIR-CSIR, India |
Abstract: | The condensation of 4-hydroxy-3-acetyl-1H-quinoline-2-one 1 and substitutedbenzaldehydes 2a-i in DMSO solution at room temperature yields quinolone chalcone derivatives 3a-i. l-Proline has been found to be an efficient catalyst for this condensation between 1 and 2. Only 5 mol% of the catalyst is necessary to achieve good yields of the products. Reactions proceed smoothly with variations of the substituents. 1 itself is synthesized by the acylation of commercially available methyl anthranilate 4 with acetoacetic ester 5 in refluxing xylene and subsequent Dieckman intramolcular cyclization of the intermediary 2-methoxycarbonylanilide 6. |
Page(s): | 855-859 |
URI: | http://hdl.handle.net/123456789/14232 |
ISSN: | 0975-0983(Online); 0376-4699(Print) |
Appears in Collections: | IJC-B Vol.51B(06) [June 2012] |
Files in This Item:
File | Description | Size | Format | |
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IJCB 51B(6) 855-859.pdf | 78.25 kB | Adobe PDF | View/Open |
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