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|Title:||L-Proline as an efficient catalyst for synthesis of N-heterocyclic chalcones as potential antibacterial agents|
|Authors:||Bhupathi, Raja S|
Devi, B Rama
Dubey, P K
|Abstract:||The condensation of 4-hydroxy-3-acetyl-1H-quinoline-2-one 1 and substitutedbenzaldehydes 2a-i in DMSO solution at room temperature yields quinolone chalcone derivatives 3a-i. l-Proline has been found to be an efficient catalyst for this condensation between 1 and 2. Only 5 mol% of the catalyst is necessary to achieve good yields of the products. Reactions proceed smoothly with variations of the substituents. 1 itself is synthesized by the acylation of commercially available methyl anthranilate 4 with acetoacetic ester 5 in refluxing xylene and subsequent Dieckman intramolcular cyclization of the intermediary 2-methoxycarbonylanilide 6.|
|Appears in Collections:||IJC-B Vol.51B(06) [June 2012]|
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