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Title: | Studies on novel polycyclic heterocycles: synthesis of new naphthaquinoxaline and naphthazaquinoxaline derivatives from naturally occurring quinones |
Authors: | Singh, Pahup Dandia, Anshu Khandelwal, Poonam |
Keywords: | Lapachol;β-lapachone;1,2-diamines;Regioisomers |
Issue Date: | Mar-2008 |
Publisher: | CSIR |
Abstract: | A facile synthesis of novel polycyclic heterocycles namely naphthaquinoxaline and naphthazaquinoxaline derivatives is carried out by the reaction of lapachol and β-lapachone, naturally occurring naphthoquinones with o-phenylene diamine and 2,3-diaminopyridine. Regioselectivity in the reaction of β-lapachone with 2,3-diaminopyridine is confirmed by single crystal X-ray diffraction of a representative compound 6,7-dihydro-8,8-dimethyl-8H-pyrano[3',2':4]-naphtha[2,1-e]pyrido[2,3-b]pyrazine; C₂₀H₁₇N₃O, crystallizes as orthorhombic in the space group Pbca with cell parameters a =9.793(3)Å, b=17.514(6)Å, c=18.334(6)Å, V=3144.5(17) ų, Z=8,1.332 mg/m³, R₁=0.3076, WR₂=0.3595. |
Page(s): | 427-433 |
URI: | http://hdl.handle.net/123456789/1423 |
ISSN: | 0376-4699 |
Appears in Collections: | IJC-B Vol.47B(03) [March 2008] |
Files in This Item:
File | Description | Size | Format | |
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IJCB 47B(3) (2008) 427-433.pdf | 206.52 kB | Adobe PDF | View/Open |
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