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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(06) [June 2012] >
| Title: | Effect of Nigella sativa seeds extracts on iNOS through antioxidant potential only: Crude/total extract as molecular therapy drug |
| Authors: | Tripathi, Yamini B
Chaturvedi, AP
Pandey, Nidhi |
| Keywords: | Antioxidant
Anti-inflammatory
Food supplements
Nigella sativa |
| Issue Date: | Jun-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | There is general belief that only pure phytomolecules may be used as
molecular therapeutic agent through one to one action. However, the traditional
systems of medicine e.g. Ayurveda, uses the crude extracts, mostly water
decoctions and oils, as drug. A comparative study of hexane, ethyl acetate and
methanol fractions of N. Sativa seeds has been carried out on
fresh rat-peritoneal-macrophage culture with reference to their role on various
targets of lipopolysaccharide induced release of nitric oxide (NO) and
inducible nitric oxide synthase (iNOS) expression. The results indicated
significant antioxidant potential with methanolic extract as most effective.
Its mechanism of action was proposed primarily through its antioxidant
potential and not through direct inhibition of other kinases, involved in its
signaling cascade. |
| Page(s): | 413-418 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(06) [June 2012]
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