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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(06) [June 2012] >
| Title: | Moringa oleifera Lam. leaf extract prevents early liver injury and restores antioxidant status in mice fed with high-fat diet |
| Authors: | Das, Nilanjan
Sikder, Kunal
Ghosh, Santinath
Fromenty, Bernard
Dey, Sanjit |
| Keywords: | Antioxidant
Hepatoprotection
High fat-diet
MoLE
Moringa oleifera leaf
NAFLD |
| Issue Date: | Jun-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Consumption of high-fat diet (HFD) induces
nonalcoholic fatty liver disease (NAFLD) and may lead to multiple complications
affecting human health. In the present study, effect of Moringa oleifera leaf extract (MoLE) in alleviating HFD induced liver injury in mice has been reported.
Liver histology and serum activity of hepatic marker enzymes i.e. aspartate
aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase
(ALP) have been studied. Lipid peroxidation (LPO), ferric reducing antioxidant
power (FRAP) and reduced glutathione (GSH) were also estimated using liver
homogenate. Results of the study suggested that MoLE treatment protected
HFD-induced liver damage as indicated by histopathology and liver enzyme
activity compared to only-HFD fed group (P<0.05).
Interestingly, early signs of HFD-induced
fatty liver were also alleviated by MoLE. Moreover, significant increase
in endogenous antioxidant parameters and lower lipid peroxidation were found in
liver of all MoLE treated groups. Results of the study indicated that MoLE has
both preventive as also curative hepatoprotective activity. |
| Page(s): | 404-412 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(06) [June 2012]
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