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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(06) [June 2012] >
| Title: | Elucidation of neuroprotective role of endogenous GABA and energy metabolites in middle cerebral artery occluded model in rats |
| Authors: | Ramanathan, M
Babu, C Saravana
Justin, A
Shanthakumari, S |
| Keywords: | ATP
Aspartate
Cerebral ischemia
Glutamate
Glutathione
Neuroprotection |
| Issue Date: | Jun-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The excitatory amino acids (EAA) like glutamate, aspartate and inhibitory
neurotransmitter GABA (gama amino butyric acid) play an important role in the
pathophysiology of cerebral ischemia. The objective of the present study is to
elucidate the role of endogenous GABA against EAA release in different regions
during ischemia. The transient focal ischemia was induced in rats by using
middle cerebral artery occlusion model (MCAo). The results indicate gradual
elevation of brain glutamate, aspartate and GABA level at different brain
regions and attained peak level at 72 h of ischemic reperfusion (IR). At 168 h
of IR the EAA levels declined to base line but GABA level was found to be still
elevated. The biochemical analysis shows the depleted brain ATP, Na+K+ATPase
content and triphasic response of glutathione activity. It can be concluded that time
dependent variation in the EAA and GABA release, endogenous GABA can be
neuroprotective and earlier restoration of energy deprivation is essential to
prevent further neurodegeneration. To have efficient treatment in ischemic
condition, multiple approaches like energy supply, antagonism of EAA,
controlling calcium function are essential. |
| Page(s): | 391-397 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(06) [June 2012]
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