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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(06) [June 2012] >
| Title: | Hyaluronic acid with or without bone marrow derived-mesenchymal stem cells improves osteoarthritic knee changes in rat model: A preliminary report |
| Authors: | Suhaeb, Abdulrazzaq Mahmod
Naveen, Sangeetha
Mansor, Azura
Kamarul, Tunku |
| Keywords: | Hyaluronic acid
Mesenchymal stem cells
Monosodium iodoacetate
Osteoarthritis rat model |
| Issue Date: | Jun-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Despite being a
complex degenerative joint disease, studies on osteoarthritis (OA) suggest that
its progression can be reduced by the use of hyaluronic acid (HA) or
mesenchymal stem cells (MSC). The present study thus aims to examine the
effects of MSC, HA and the combination of HA-MSC in treating OA in rat model. The histological observations using O’Driscoll score
indicate that it is
the use of HA and MSC independently and not their combination that delays the
progression of OA. In
conclusion, the preliminary study suggest that the use of either HA or MSCs
effectively reduces OA progression better than their combined use. |
| Page(s): | 383-390 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(06) [June 2012]
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