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|Title:||Sustained stomach specific delivery of piroxicam from floating emulsion polyelectrolyte complex beads|
Pandit, Jayant K
|Keywords:||Chitosan;Emulsion PEC beads;Floating drug delivery;Gelucire;Piroxicam|
|Abstract:||This study presents development of floating emulsion polyelectrolyte complex (PEC) beads based on gellan-chitosan PEC and Gelucire 39/01 and 50/13 without using any chemical crosslinker, and release from developed beads of piroxicam (PRM) in 0.1 M HCl (pH 1.2). Developed beads showed excellent buoyancy, significantly improved encapsulation efficiency and sustained release of PRM compared to floating gellan-chitosan beads bearing PRM. Thus emulsion PEC beads may form a potential stomach site specific drug delivery system for PRM delivery.|
|ISSN:||0975-1084 (Online); 0022-4456 (Print)|
|Appears in Collections:||JSIR Vol.71(06) [June 2012]|
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