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Title: Sustained stomach specific delivery of piroxicam from floating emulsion polyelectrolyte complex beads
Authors: Verma, Anurag
Dixit, Raghav
Pandit, Jayant K
Keywords: Chitosan;Emulsion PEC beads;Floating drug delivery;Gelucire;Piroxicam
Issue Date: Jun-2012
Publisher: NISCAIR-CSIR, India
Abstract: This study presents development of floating emulsion polyelectrolyte complex (PEC) beads based on gellan-chitosan PEC and Gelucire 39/01 and 50/13 without using any chemical crosslinker, and release from developed beads of piroxicam (PRM) in 0.1 M HCl (pH 1.2). Developed beads showed excellent buoyancy, significantly improved encapsulation efficiency and sustained release of PRM compared to floating gellan-chitosan beads bearing PRM. Thus emulsion PEC beads may form a potential stomach site specific drug delivery system for PRM delivery.
Page(s): 407-412
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Appears in Collections:JSIR Vol.71(06) [June 2012]

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