|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemical Technology (IJCT) >
IJCT Vol.19 [2012] >
IJCT Vol.19(3) [May 2012] >
| Title: | Extractive spectrophotometric methods for determination of terbinafine hydrochloride in pharmaceutical formulations using some acidic triphenylmethane dyes |
| Authors: | Chennaiah, M
Veeraiah, T
Kumar, T Vinod
Venkateshwarlu, G |
| Keywords: | Bromocresol green
Bromophenol blue
Bromothymol blue
Spectrophotometry
Terbinafine hydrochloride |
| Issue Date: | May-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Three simple and sensitive extractive spectrophotometric methods have been
described for the assay of terbinafine hydrochloride either in pure form or in
pharmaceutical formulations. The developed methods involve formation of
coloured chloroform extractable ion-pair complexes of the drug with bromothymol
blue (BTB), bromophenol blue (BPB) and bromocresol green (BCG) in acidic
medium. The extracted complexes show absorbance maxima at 410 nm for all three
methods. Beer’s law is obeyed in the concentration ranges 2.0-25, 2.0-25 and
2.0-25 µg/mL with BTB, BPB and BCG respectively. The effects of concentration
of dye, pH, and interference of
excipients have been studied and optimized. The limits of detection and
quantification have been determined for three methods. All the three methods
have been validated as per the guidelines of ICH. The methods have been applied
for the determination of drug in commercial tablets and the results of analysis
are validated statistically through recovery studies. |
| Page(s): | 218-221 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0991 (Online); 0971-457X (Print) |
| Source: | IJCT Vol.19(3) [May 2012]
|
|
