NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemical Technology (IJCT) >
IJCT Vol.19 [2012] >
IJCT Vol.19(3) [May 2012] >


Title: Extractive spectrophotometric methods for determination of terbinafine hydrochloride in pharmaceutical formulations using some acidic triphenylmethane dyes
Authors: Chennaiah, M
Veeraiah, T
Kumar, T Vinod
Venkateshwarlu, G
Keywords: Bromocresol green
Bromophenol blue
Bromothymol blue
Spectrophotometry
Terbinafine hydrochloride
Issue Date: May-2012
Publisher: NISCAIR-CSIR, India
Abstract: Three simple and sensitive extractive spectrophotometric methods have been described for the assay of terbinafine hydrochloride either in pure form or in pharmaceutical formulations. The developed methods involve formation of coloured chloroform extractable ion-pair complexes of the drug with bromothymol blue (BTB), bromophenol blue (BPB) and bromocresol green (BCG) in acidic medium. The extracted complexes show absorbance maxima at 410 nm for all three methods. Beer’s law is obeyed in the concentration ranges 2.0-25, 2.0-25 and 2.0-25 µg/mL with BTB, BPB and BCG respectively. The effects of concentration of dye, pH, and interference of excipients have been studied and optimized. The limits of detection and quantification have been determined for three methods. All the three methods have been validated as per the guidelines of ICH. The methods have been applied for the determination of drug in commercial tablets and the results of analysis are validated statistically through recovery studies.
Page(s): 218-221
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0991 (Online); 0971-457X (Print)
Source:IJCT Vol.19(3) [May 2012]

Files in This Item:

File Description SizeFormat
IJCT 19(3) 218-221.pdf54.59 kBAdobe PDFView/Open
 Current Page Visits: 616 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 636795 since 06-Feb-2009  Last updated on 15-Dec-2014Webmaster: nopr@niscair.res.in