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|Title:||Reactions of 5-benzoyl-/5-carbaldehyde- /5-(3-phenyl-acryloyl)- 6-hydroxy-1H-pyrimidin- 2,4-diones with amines: Anti-cancer and metal sequestering properties|
|Keywords:||5-Acylpyrimidines;Amine;Enamines;Anti-cancer activities;Metal chelators|
|Abstract:||Reactions of 5-benzoyl- / 5-carbaldehyde- / 5-(3-phenyl-acryloyl)-6-hydroxy-1H- pyrimidine-2,4-diones and diamines result in the formation of corresponding enamines. Appreciable anti-cancer activities of compounds 2, 5, 6 and 8 at various cell lines of 59 human tumor cell panels have been observed. UV spectral studies of these compounds in solution with Cu(OAc)₂ and FeCl₃ indicate their interactions with Cu⁺² and Fe⁺³ ions.|
|Appears in Collections:||IJC-B Vol.47B(02) [February 2008]|
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|IJCB 47B(2) (2008) 291-296.pdf||142.14 kB||Adobe PDF||View/Open|
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