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IJC-B Vol.47B(02) [February 2008] >

Title: Reactions of 5-benzoyl-/5-carbaldehyde- /5-(3-phenyl-acryloyl)- 6-hydroxy-1H-pyrimidin- 2,4-diones with amines: Anti-cancer and metal sequestering properties
Authors: Singh, Palwinder
Kaur, Jatinder
Paul, Kamaldeep
Keywords: 5-Acylpyrimidines
Anti-cancer activities
Metal chelators
Issue Date: Feb-2008
Publisher: CSIR
Abstract: Reactions of 5-benzoyl- / 5-carbaldehyde- / 5-(3-phenyl-acryloyl)-6-hydroxy-1H- pyrimidine-2,4-diones and diamines result in the formation of corresponding enamines. Appreciable anti-cancer activities of compounds 2, 5, 6 and 8 at various cell lines of 59 human tumor cell panels have been observed. UV spectral studies of these compounds in solution with Cu(OAc)₂ and FeCl₃ indicate their interactions with Cu⁺² and Fe⁺³ ions.
Page(s): 291-296
ISSN: 0376-4699
Source:IJC-B Vol.47B(02) [February 2008]

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