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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.47B [2008] >
IJC-B Vol.47B(02) [February 2008] >
| Title: | Reactions of 5-benzoyl-/5-carbaldehyde- /5-(3-phenyl-acryloyl)- 6-hydroxy-1H-pyrimidin- 2,4-diones with amines: Anti-cancer and metal sequestering properties |
| Authors: | Singh, Palwinder
Kaur, Jatinder
Paul, Kamaldeep |
| Keywords: | 5-Acylpyrimidines
Amine
Enamines
Anti-cancer activities
Metal chelators |
| Issue Date: | Feb-2008 |
| Publisher: | CSIR |
| Abstract: | Reactions of 5-benzoyl- / 5-carbaldehyde- / 5-(3-phenyl-acryloyl)-6-hydroxy-1H- pyrimidine-2,4-diones and diamines result in the formation of corresponding enamines. Appreciable anti-cancer activities of compounds 2, 5, 6 and 8 at various cell lines of 59 human tumor cell panels have been observed. UV spectral studies of these compounds in solution with Cu(OAc)₂ and FeCl₃ indicate their interactions with Cu⁺² and Fe⁺³ ions. |
| Page(s): | 291-296 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.47B(02) [February 2008]
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