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IJEB Vol.50(05) [May 2012] >


Title: Antitumor potential of Castanopsis indica (Roxb. ex Lindl.) A. DC. leaf extract against Ehrlich's ascites carcinoma cell
Authors: Dolai, Narayan
Karmakar, Indrajit
Kumar, R B Suresh
Bala, Asis
Mazumder, U K
Haldar, Pallab Kanti
Keywords: Antioxidant
Antitumor
Castanopsis indica
Cytotoxicity
EAC cell
Issue Date: May-2012
Publisher: NISCAIR-CSIR, India
Abstract: Methanol extract of C. indica (MECI) leaves showed direct cytotoxicity on Ehrlich ascites carcinoma (EAC) cell in a dose dependant manner and there was significant decrease in the tumor volume, viable cell count, tumor weight and elevated the life span of EAC tumor bearing mice. Hematological profile and biochemical estimations were significantly restored to normal levels in MECI treated as compared to EAC control mice. MECI treatment significantly modulated the tissue antioxidant assay parameters as compared to the EAC control mice. The results revealed that MECI possesses significant dose dependent antitumor potential which may be due to its cytotoxicity and antioxidant properties.
Page(s): 359-365
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.50(05) [May 2012]

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