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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(05) [May 2012] >
| Title: | Antitumor potential of Castanopsis indica (Roxb. ex Lindl.) A. DC. leaf extract against Ehrlich's ascites carcinoma cell |
| Authors: | Dolai, Narayan
Karmakar, Indrajit
Kumar, R B Suresh
Bala, Asis
Mazumder, U K
Haldar, Pallab Kanti |
| Keywords: | Antioxidant
Antitumor
Castanopsis indica
Cytotoxicity
EAC cell |
| Issue Date: | May-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Methanol extract of C.
indica (MECI) leaves showed direct cytotoxicity on Ehrlich ascites carcinoma (EAC) cell in
a dose dependant manner and there was significant decrease in the tumor volume,
viable cell count, tumor weight and elevated the life span of EAC tumor bearing
mice. Hematological profile and biochemical estimations were
significantly restored to normal levels in MECI treated as compared to
EAC control mice. MECI treatment significantly modulated the tissue
antioxidant assay parameters as compared to the EAC control mice. The results revealed
that MECI possesses significant dose dependent antitumor potential which may be
due to its cytotoxicity and antioxidant properties. |
| Page(s): | 359-365 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(05) [May 2012]
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