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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(05) [May 2012] >
| Title: | Antihyperglycemic activity of Woodfordia fruticosa (Kurz) flowers extracts in glucose metabolism and lipid peroxidation in streptozotocin-induced diabetic rats |
| Authors: | Verma, Neeraj
Amresh, G
Sahu, P K
Rao, Ch V
Singh, Anil Pratap |
| Keywords: | Antihyperglycemic
Antioxidant
Diabetes mellitus
Streptozotocin
Woodfordia fruticosa |
| Issue Date: | May-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The
ethanolic extract of W. fruticosa flowers (250 and 500 mg/kg)
significantly reduced fasting blood glucose level and increased insulin level
after 21 days treatment in streptozotocin diabetic rats. The extract also
increased catalase, superoxide dismutase, glutathione reductase, glutathione peroxidase activities
significantly and reduced lipid peroxidation. Glycolytic enzymes showed a
significant increase in their levels while a significant decrease was observed
in the levels of the gluconeogenic enzymes in ethanolic extract treated
diabetic rats. The extract has a favourable effect on the histopathological
changes of the pancreatic β- cells in streptozotocin induced diabetic rats. The
results suggest that W. fruticosa possess
potential antihyperglycemic effect by regulating glucose homeostasis and antioxidant
efficacy in streptozotocin-induced diabetic rats. |
| Page(s): | 351-358 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(05) [May 2012]
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