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|Title:||Facile synthesis of some new steroidal pyrazoline and 1′,3′,4′-oxadiazole|
Alam, Mohd Gulfam
|Keywords:||Steroidal pyrazoline and oxadiazole;Methyl acetoacetate;4-chlorobenzoic acid;Phosphorous oxy¬chloride;4-ethylbenzoyl chloride|
|Abstract:||Title compounds, 3β-[(3′-methyl-5′-oxo-2′-pyrazolin-1′-yl)carbonylmethoxy]cholest-5-ene 4, 3β-[5′-phenyl-1′,3′,4′-oxadiazol-2′-yl]methoxycholest-5-ene 5, 3β-[5′-(4′′-chlorophenyl)-1′,3′,4′-oxadiazol-2′-yl]methoxycholest-5-ene 6, 3β-[5′-(4′′-ethylphenyl)-1′,3′,4′-oxadiazole-2′-yl)methoxycholest-5-ene 7 have been prepared by the cyclization of cholest-5-en-3β-O-acetyl hydrazide 3 using methyl acetoacetate, benzoic acid, 4-chlorobenzoic acid and 4-ethylbenzoyl chloride in presence of phosphorous oxychloride through conventional heating. Compound 5 has been prepared by two different ways.|
|Appears in Collections:||IJC-B Vol.51B(05) [May 2012]|
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