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Title: Conventional and microwave-assisted synthesis of pyrazole derivatives and screening of their antibacterial and antifungal activities
Authors: Mistry, B D
Desai, K R
Patel, J A
Patel, N I
Keywords: Quinoline;Pyrazole;Antibacterial;Antifungal;Microwave irradiation
Issue Date: May-2012
Publisher: NISCAIR-CSIR, India
Abstract: 5-{2′-Chloro-6′-methyl-(3′-quinolyl)}-3-(substitutedphenyl) pyrazole 3a-j, 5-{2′-chloro-6′-methyl-(3′-quinolyl)}-3-(substitutedphenyl) pyrazole carboxamide 4a-j and 5-{2′-chloro-6′-methyl-(3′-quinolyl)}-3-(substitutedphenyl) pyrazole carbothiamide 5a-j have been synthesized by the reaction of 3-(2′-chloro-6′-methyl(3′-quinolyl))-1-(substitutedphenyl)prop-2-en-1-one 2a-j with hydrazine hydrate, semicarbazide hydrochloride and thiosemicarbazide hydrochloride respectively. These compounds have been screened for their antibacterial and antifungal activities against different microorganisms. The structures of novel synthesized compounds have been established on the basis of elemental analysis, IR, 1H NMR and mass spectral data.
Page(s): 746-751
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(05) [May 2012]

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