20-May-2013
22:59:08 IST
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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.51B [2012] >
IJC-B Vol.51B(05) [May 2012] >
| Title: | Synthesis and antibacterial evaluation of benzazoles tethered dihydro[1,3]oxazines |
| Authors: | Prasad, Davinder
Rohilla, Rajesh Kumar
Roy, Nilanjan
Nath, Mahendra |
| Keywords: | One-pot methodology
Antibacterial efficacy
Benzazoles
Dihydro[1,3]oxazines
Polymerization |
| Issue Date: | May-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Synthesis of various
benzazoles tethered 1,3-oxazines such as 1H-benzo[d]azolophenyl-3,4-dihydro-2H-benzo[e][1,3]oxazines 2a-j,
2-(3-(1H-benzo[d]oxazol-2-yl)phenyl)-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine
3, 2-(3-(1H-benzo-[d]imidazol-2-yl)phenyl)-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine 4 and
3-(3-(benzo[d]oxazol-2-yl)phenyl)-7-(benzo[d]thiazol-2-yl)-3,4-dihydro-2H-benzo[e][1,3]oxazine 5 has
been accomplished through three-component one-pot Mannich type
condensation-cyclization reaction of substituted phenols or β-naphthol with
formaldehyde and benzazolophenyl amines at 80-90°C. All the newly synthesized compounds have been
characterized on the basis of elemental and spectral analyses. Moreover, these
compounds have been evaluated for their in
vitro antibacterial efficacy against two Gram-positive bacteria viz S.
epidermidis and S. aureus and two
Gram-negative bacteria viz E. coli and P. aeruginosa. Interestingly, the compounds, 2f-i have displayed significant antibacterial efficacy with IC50
(0.208-1.106 µg/mL). |
| Page(s): | 739-745 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.51B(05) [May 2012]
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