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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.51B [2012] >
IJC-B Vol.51B(05) [May 2012] >
| Title: | Synthesis of novel heteroarenes based [1,2,3]-triazoles via click chemistry and their evaluation for antibacterial activity |
| Authors: | Prasad, Davinder
Aggarwal, Nisha
Kumar, Rajesh
Nath, Mahendra |
| Keywords: | Heteroarenes
[1,2,3]-triazoles
Click chemistry
Antibacterial activity
Alkynes
Heteroarylazides |
| Issue Date: | May-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A series of
heteroarenes based [1,2,3]-triazole derivatives 8a-h and 9a-f has been
synthesized via click chemistry
through Huisgen [2+3] cycloaddition reaction of heteroarylazides 7a-e with alkynes (3a-c, propargyl alcohol or phenyl acetylene) in the presence of
CuSO4.5H2O and sodium ascorbate in t-butanol and water (1:1) mixture at 25°C in good to excellent yields (74-94%). All the newly
synthesized compounds have been characterized on the basis of analytical and
spectral data. The compounds 8a, 8e, 9a, 9b, 9c and 9e have been evaluated for their preliminary in-vitro antibacterial efficacy against a panel of two
Gram-positive bacteria viz. Staphylococcus
aureus and Streptococcus mutans
and two Gram-negative bacteria viz. Escherichia
coli and Pseudomonas aeruginosa using the Agar disc diffusion method. |
| Page(s): | 731-738 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.51B(05) [May 2012]
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