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IJC-B Vol.47B(01) [January 2008] >

Title: Formation and antimicrobial activity of 2-azetidinones from selective ester cleavage in 1,3,3-trisubstituted 4-[2-(O-diarylacyl) hydroxyphenyl]-2- azetidinones
Authors: Singh, G S
Pheko, T
Keywords: Azetidinones
Antimicrobial activity
HMQC study
HMBC study
Issue Date: Jan-2008
Publisher: CSIR
Abstract: Treatment of the 1,3,3-trisubstituted 4-[2'-(O-diarylacyl)hydroxyphenyl]-2-azetidinones with sodium hydroxide in ethanol at room temperature lead to selective cleavage of the ester linkage in the substrates forming new 1,3,3-trisubstituted 4-(2'-hydroxyphenyl)-2-azetidinones, which have been characterized on the basis of analytical and spectral (IR, ¹H and ¹³C NMR, MS) data. The structure elucidation also involves application of the HMQC and HMBC studies using 2-D NMR (¹H-¹³C COSY) spectra. The antibacterial and antifungal activities of the products are reported.
Page(s): 159-162
ISSN: 0376-4699
Source: IJC-B Vol.47B(01) [January 2008]

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