Please use this identifier to cite or link to this item:
|Title:||Formation and antimicrobial activity of 2-azetidinones from selective ester cleavage in 1,3,3-trisubstituted 4-[2-(O-diarylacyl) hydroxyphenyl]-2- azetidinones|
|Authors:||Singh, G S|
|Abstract:||Treatment of the 1,3,3-trisubstituted 4-[2'-(O-diarylacyl)hydroxyphenyl]-2-azetidinones with sodium hydroxide in ethanol at room temperature lead to selective cleavage of the ester linkage in the substrates forming new 1,3,3-trisubstituted 4-(2'-hydroxyphenyl)-2-azetidinones, which have been characterized on the basis of analytical and spectral (IR, ¹H and ¹³C NMR, MS) data. The structure elucidation also involves application of the HMQC and HMBC studies using 2-D NMR (¹H-¹³C COSY) spectra. The antibacterial and antifungal activities of the products are reported.|
|Appears in Collections:|| IJC-B Vol.47B(01) [January 2008]|
Files in This Item:
|IJCB 47B(1) (2008) 159-162.pdf||51.61 kB||Adobe PDF||View/Open|
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.