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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.47B [2008] >
IJC-B Vol.47B(01) [January 2008] >
| Title: | Formation and antimicrobial activity of 2-azetidinones from selective ester cleavage in 1,3,3-trisubstituted 4-[2-(O-diarylacyl) hydroxyphenyl]-2- azetidinones |
| Authors: | Singh, G S
Pheko, T |
| Keywords: | Azetidinones
Antimicrobial activity
HMQC study
HMBC study |
| Issue Date: | Jan-2008 |
| Publisher: | CSIR |
| Abstract: | Treatment of the 1,3,3-trisubstituted 4-[2'-(O-diarylacyl)hydroxyphenyl]-2-azetidinones with sodium hydroxide in ethanol at room temperature lead to selective cleavage of the ester linkage in the substrates forming new 1,3,3-trisubstituted 4-(2'-hydroxyphenyl)-2-azetidinones, which have been characterized on the basis of analytical and spectral (IR, ¹H and ¹³C NMR, MS) data. The structure elucidation also involves application of the HMQC and HMBC studies using 2-D NMR (¹H-¹³C COSY) spectra. The antibacterial and antifungal activities of the products are reported. |
| Page(s): | 159-162 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.47B(01) [January 2008]
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