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Title: Homology modeling and enzyme function prediction in uncharacterized proteins of Salmonella typhi—An in silico approach
Authors: Gore, D G
Rathod, M K
Soni, V
Rai, M M
Keywords: CDD-BLAST
Function prediction
Homology modeling
Hypothetical proteins
Salmonella typhi
Issue Date: Apr-2012
Publisher: NISCAIR-CSIR, India
Abstract: Salmonella typhi, a known human pathogen registering multiple drug resistance, causes majority of endemic cases in developing nations. S. typhi genome was marked with the 1220 ORFs for hypothetical proteins. Enzyme coding probability was searched in hypothetical proteins using web tools like CDD-BLAST, InterProScan, Pfam and COGs. Study sorted out 213 proteins as enzyme coding and for these proteins tertiary structures were predicted based on the homology modeling. About 89 structures were modeled for functional proteins and such a deciphered structure-function relationship could help in detail understanding of regulatory network of S. typhi and establishing new function in uncharacterized regions.
Page(s): 224-234
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Source:IJBT Vol.11(2) [April 2012]

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