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|Title:||Synthesis and anti-tuberculosis activity of 2,4-disubstituted quinolines|
|Keywords:||Tuberculosis;Ring-substituted quinolines;Drug-sensitive TB;Drug-resistant TB;Multi-drug resistant TB;Extreme drug-resistant TB|
|Abstract:||Synthesis and anti-tuberculosis activity of a new series of 2,4-disubstituted quinolines have been reported. The most promising compounds have been found to exhibit 99% inhibition at 6.25 μg/mL against drug-sensitive M. tuberculosis H37Rν strain and >90% inhibition at 12.5 μg/mL against isoniazid resistant TB strain.|
|Appears in Collections:|| IJC-B Vol.47B(01) [January 2008]|
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|IJCB 47B(1) (2008) 117-128.pdf||128.49 kB||Adobe PDF||View/Open|
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