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Title: Synthesis and anti-tuberculosis activity of 2,4-disubstituted quinolines
Authors: Nayyar, Amit
Jain, Rahul
Keywords: Tuberculosis;Ring-substituted quinolines;Drug-sensitive TB;Drug-resistant TB;Multi-drug resistant TB;Extreme drug-resistant TB
Issue Date: Jan-2008
Publisher: CSIR
Abstract: Synthesis and anti-tuberculosis activity of a new series of 2,4-disubstituted quinolines have been reported. The most promising compounds have been found to exhibit 99% inhibition at 6.25 μg/mL against drug-sensitive M. tuberculosis H37Rν strain and >90% inhibition at 12.5 μg/mL against isoniazid resistant TB strain.
Page(s): 117-128
ISSN: 0376-4699
Appears in Collections: IJC-B Vol.47B(01) [January 2008]

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