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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biotechnology (IJBT) >
IJBT Vol.11 [2012] >
IJBT Vol.11(2) [April 2012] >
| Title: | MicroRNA profile in understanding pathogenesis of systemic lupus erythematosus |
| Authors: | Pradhan, Vandana
Hire, Harshada
Ghosh, K |
| Keywords: | Autoimmune disorder
microRNA (miRNA)
systemic lupus erythematosus (SLE) |
| Issue Date: | Apr-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Systemic lupus erythematosus (SLE) is a
systemic autoimmune disease caused by genetic and epigenetic alterations as
well as environmental factors. SLE is a multisystem disease whose pathogenesis
is poorly understood. Current therapies are based
on nonspecific immunosuppression but till date no permanent cure has
been documented for SLE. Recent advances in RNA interference have opened new
directions for SLE pathogenesis, more significant being the discovery of
microRNAs (miRNAs). miRNAs are small, evolutionary conserved, non-coding, RNA
molecules. Emerging evidences show that miRNAs affect the stability and
translational efficiency of messenger RNAs (mRNAs) by post transcriptionally
regulating gene expression of the target mRNAs. miRNAs play a vital role in
development, regulation and prevention of immune diseases. The potential of
miRNAs as diagnostic biomarkers and therapeutic agents is extensively studied
by researchers worldwide. In this article, various miRNAs associated with SLE
pathogenesis and their associated mechanisms in cellular processes have been
reviewed.
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| Page(s): | 129-133 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0967 (Online); 0972-5849 (Print) |
| Source: | IJBT Vol.11(2) [April 2012]
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