NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.47B [2008] >
IJC-B Vol.47B(01) [January 2008] >

Title: Synthesis and antitubercular,antiviral and anticancer activity of 3-(3-mercaptoalkyl-7H-[1,2,4]triazolo [3,4-b][1,3,4]-thiadiazin-6-yl) chromen-2-one and its derivatives
Authors: Kumar, P Vijaya
Rao, V Rajeswar
Keywords: Benzopyran-2-one
Issue Date: Jan-2008
Publisher: CSIR
Abstract: 3-(3-Mercaptoalkyl-7H-[1,2,4] triazolo[3,4-b][1,3,4]thiadiazin-6-yl)- chromen-2-one 3 have been prepared by the condensation of 3-(2-bromoacetyl)coumarin 1 and 4-amino-5-mercaptoalkyl-4H-[1,2,4]triazole-3- thiol 2 in anhydrous ethanol. Similarly the 7,8-benzo analagues of 1 on reaction with 2 resulted in the formation of 7,8-benzo derivatives of 3s-x. Reaction of 3a with phenacyl chloride in anhydrous ethanol gave corresponding 3-(3-(2-oxo-2-phenylethylsulphanylmethyl)-7H- [1,2,4]triazolo[3,4-b][1,3,4] thiadiazin-6-yl]chromen-2-one 4. The 7,8-benzo analogues of 3s-t on treatment with phenacyl chloride in anhydrous ethanol under reflux gave 4g and 4h. The newly synthesized compounds are characterized on the basis of elemental analysis, IR, ¹H NMR and mass spectral data. Some of the compounds are screened for their antitubercular, antiviral and anticancer activities.
Page(s): 106-111
ISSN: 0376-4699
Source: IJC-B Vol.47B(01) [January 2008]

Files in This Item:

File Description SizeFormat
IJCB 47B(1) (2008) 106-111.pdf120.55 kBAdobe PDFView/Open
 Current Page Visits: 119 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 163732 since 01-Sep-2015  Last updated on 21-Jun-2016Webmaster: