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IJC-B Vol.47B [2008] >
IJC-B Vol.47B(01) [January 2008] >


Title: Design and synthesis of non-cytotoxic tetrahydrothieno[3,2-c]pyridine derivatives exhibiting complement inhibition activity
Authors: Master, Hoshang E
Khan, Shabana I
Poojari, Krishna A
Keywords: Tetrahydrothieno[3,2-c]pyridine
Non-cytotoxic
Complement inhibition
Haemolysis
Classical pathway
Issue Date: Jan-2008
Publisher: CSIR
Abstract: A series of 4,5,6,7-tetrahydrothieno[3,2-c]pyridine derivatives have been synthesized and evaluated for their activity on the activation of human complement (classical pathway) and their intrinsic haemolytic activity. The in vitro assay results of these analogues for inhibition of complement activity reveals improved inhibitory activity for some of the analogues over existing tetrahydrothienopyridine derivatives like Ticlopidine and Clopidogrel. Significantly, these analogues did not exhibit any haemolytic activity and are non-cytotoxic to human cell lines
Page(s): 97-105
ISSN: 0376-4699
Source: IJC-B Vol.47B(01) [January 2008]

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