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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Traditional Knowledge (IJTK) >
IJTK Vol.11 [2012] >
IJTK Vol.11(2) [April 2012] >
| Title: | Podophyllum L.: An endergered and anticancerous medicinal plant–An overview |
| Authors: | Chaurasia, OP
Ballabh, B
Tayade, A
Kumar, Raj
Kumar, G Phani
Singh, SB |
| Keywords: | Mayapple
Lignan
Etoposide
Teniposide
Podophyllotoxin
Podophyllum hexandrum |
| Issue Date: | Apr-2012 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. Cl.8: A601K 36/00, A61, A01N 3/00, C01, C12, C09C, C08L 97/00 |
| Abstract: | Podophyllum hexandrum Royle syn P. emodi Wall. ex Hook.f. & Thoms.
is an endangered and valuable medicinal plant, distributed in the Himalayan
zone at an altitudes ranging from 2000 to 4000 m above MSL. It is an herbaceous
and rhizomatous perennial plant also found in few pockets of Indian cold desert
(Ladakh and Lahaul-Spiti). Its rhizomes and roots contain about 8% of
podophylloresin from which several lignans were isolated. Amongst the most important
being podophyllotoxin (4% on a dry weight basis) which has cytotoxic and
antitumour properties, and also used in the treatment of certain forms of
cancer. In past few years, the frequency of this species in nature has declined
considerably because of unscientific exploitation to meet the everincreasing
demand of pharmaceutical sector. Podophyllum
hexandrum has an increasing demand in national and international market
because of more than double amount of podophyllotoxin content found in it, than
P. peltatum (American Podophyllum).
This article briefly reviews the botanical,
medicinal, phytochemical, pharmacological, conservation, market and trade
related aspects of the plant. An attempt has also been made to compile and
document information on other aspect of Podophyllum
hexandrum, other species of such as P.
peltatum, P. sikkimenmsis and also highlight the need for its research and
development. |
| Page(s): | 234-241 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1068 (Online); 0972-5938 (Print) |
| Source: | IJTK Vol.11(2) [April 2012]
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