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Research Journals >
Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.49 [2012] >
IJBB Vol.49(2) [April 2012] >
| Title: | Effect of sodium fluoride and magnesium chloride on different hydroxyproline fractions in rat liver |
| Authors: | Siddiqi, N J |
| Keywords: | Sodium Fluoride
Hydroxyproline
Collagen
Magnesium Chloride |
| Issue Date: | Apr-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Sodium fluoride (NaF)
is used for prevention of caries in the form of fluoridated drinking water,
fluoride tablets etc. In the present study, the effect of NaF-induced
alterations in hydroxyproline (Hyp) and collagen was investigated in rat liver.
The effect of pretreatment with MgCl2 on NaF-induced changes in
liver Hyp and collagen was also studied. The NaF treatment at
5, 10 and 20 mg/kg body wt (reported LD50 of NaF being
24 mg/kg body wt through intraperitoneal route) caused a significant decrease
in free Hyp (P<0.05), when compared to control rats. The rats treated with
20 mg/kg body wt of NaF showed a significant increase in protein-bound Hyp
(P<0.001),
as compared to control group, while of NaF treatment at 5 and
10 mg/kg body wt caused no significant change in protein-bound Hyp. All the
doses of NaF had no significant effect on peptide-bound and total Hyp and total
collagen. Treatment of with MgCl2 alone (30 mg/kg body wt) or with
NaF (10 mg/kg body wt) caused a significant decrease in free Hyp (P<0.05). MgCl2 alone and with NaF caused a
significant increase (P<0.05) in total collagen content. Thus, the present
study demonstrated that NaF had no significant effect on total Hyp and
collagen, indicating that its use in various products may not interfere with the liver collagen. |
| Page(s): | 130-133 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.49(2) [April 2012]
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