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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.49 [2012] >
IJBB Vol.49(2) [April 2012] >
| Title: | Relation of CuZnSOD activity with renal insufficiency in hypertensive diabetic patients |
| Authors: | Stancic, Ana
Rasic-Milutinovic, Zorica
Perunicic-Pekovic, Gordana
Buzadzic, Biljana
Korac, Aleksandra
Otasevic, Vesna
Jankovic, Aleksandra
Vucetic, Milica
Korac, Bato |
| Keywords: | Diabetes
Renal Insufficiency
CuZnSOD Activity |
| Issue Date: | Apr-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Diabetes and
renal insufficiency are interrelated metabolic disorders closely associated
with redox homeostasis disturbances. The aim of this study was to compare the
activity of copper zinc superoxide dismutase (CuZnSOD) in the erythrocytes of
hypertensive diabetic patients with or without renal insufficiency with normal
healthy control subjects. In both groups of diabetic patients, blood glucose
level and the content of glycosylated hemoglobin (HbA1c) were higher
than in the control group. However, CuZnSOD activity was significantly higher
than control only in hypertensive diabetic patients with renal insufficiency.
Our results suggest that disturbances in superoxide homeostasis do correlate
with long-term complication in diabetes, i.e. diabetic renal insufficiency and
hypertension. |
| Page(s): | 97-100 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.49(2) [April 2012]
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