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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.51B [2012] >
IJC-B Vol.51B(04) [April 2012] >
| Title: | Synthesis, characterization and potential anticonvulsants activity of various 3-(substituted)-benzylidene-7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one |
| Authors: | Ahmad, Bahar
Rashid, Mohd
Husain, Asif
Mishra, Ravinesh |
| Keywords: | 1,4-Benzodiazepin-2-one
Benzaldehyde Deri¬vatives
Anticonvulsant Activity
Benzodiazepine Receptors |
| Issue Date: | Apr-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A number of new
3-(substituted)-benzylidene derivatives of
7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one have been synthesized and their anticonvulsant activity tested through Maximal Electroshock
(M.E.S.) model and PTZ animal model by using
Phenytoin and Diazepam as reference drugs respectivily. The five
compounds, namely 3-(4-chlorobenzylidene)-7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
4a, 3-(2-chlorobenzylidene)-7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
4b,
3(3-hydroxybenzylidene)-7-Chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
4d, 3-(4-N, N-dimethylbenzylidene)-7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]
diazepin-2-one 4h and
3(4-florobenzylidene)-7-chloro5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one 4j have shown significant anticonvulsant activity as compared to
reference drugs. |
| Page(s): | 639-645 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.51B(04) [April 2012]
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