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|Title:||Synthesis, characterization and potential anticonvulsants activity of various 3-(substituted)-benzylidene-7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one|
|Keywords:||1,4-Benzodiazepin-2-one;Benzaldehyde Deri¬vatives;Anticonvulsant Activity;Benzodiazepine Receptors|
|Abstract:||A number of new 3-(substituted)-benzylidene derivatives of 7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one have been synthesized and their anticonvulsant activity tested through Maximal Electroshock (M.E.S.) model and PTZ animal model by using Phenytoin and Diazepam as reference drugs respectivily. The five compounds, namely 3-(4-chlorobenzylidene)-7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one 4a, 3-(2-chlorobenzylidene)-7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one 4b, 3(3-hydroxybenzylidene)-7-Chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one 4d, 3-(4-N, N-dimethylbenzylidene)-7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4] diazepin-2-one 4h and 3(4-florobenzylidene)-7-chloro5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one 4j have shown significant anticonvulsant activity as compared to reference drugs.|
|Appears in Collections:||IJC-B Vol.51B(04) [April 2012]|
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