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IJC-B Vol.51B(04) [April 2012] >

Title: Synthesis, characterization and potential anticonvulsants activity of various 3-(substituted)-benzylidene-7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
Authors: Ahmad, Bahar
Rashid, Mohd
Husain, Asif
Mishra, Ravinesh
Keywords: 1,4-Benzodiazepin-2-one
Benzaldehyde Deri¬vatives
Anticonvulsant Activity
Benzodiazepine Receptors
Issue Date: Apr-2012
Publisher: NISCAIR-CSIR, India
Abstract: A number of new 3-(substituted)-benzylidene derivatives of 7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one have been synthesized and their anticonvulsant activity tested through Maximal Electroshock (M.E.S.) model and PTZ animal model by using Phenytoin and Diazepam as reference drugs respectivily. The five compounds, namely 3-(4-chlorobenzylidene)-7-chloro-5-phen­yl-1,­3-dihydro-benzo[e][1,4]diazepin-2-one 4a, 3-(2-chloro­benzyl­i­­dene)-7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diaze­pin-2-one 4b, 3(3-hydroxybenzylidene)-7-Chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one 4d, 3-(4-N, N-dimethyl­benzylidene)-7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4] diaze­pin-2-one 4h and 3(4-florobenzylidene)-7-chloro5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one 4j have shown significant anticonvulsant activity as compared to reference drugs.
Page(s): 639-645
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.51B(04) [April 2012]

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