Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/13832
Title: Synthesis, characterization and potential anticonvulsants activity of various 3-(substituted)-benzylidene-7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
Authors: Ahmad, Bahar
Rashid, Mohd
Husain, Asif
Mishra, Ravinesh
Keywords: 1,4-Benzodiazepin-2-one
Benzaldehyde Deri¬vatives
Anticonvulsant Activity
Benzodiazepine Receptors
Issue Date: Apr-2012
Publisher: NISCAIR-CSIR, India
Abstract: A number of new 3-(substituted)-benzylidene derivatives of 7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one<b style=""> </b>have been synthesized and their anticonvulsant activity tested through Maximal Electroshock (M.E.S.) model and PTZ animal model by using Phenytoin and Diazepam as reference drugs respectivily. The five compounds, namely 3-(4-chlorobenzylidene)-7-chloro-5-phen­yl-1,­3-dihydro-benzo[e][1,4]diazepin-2-one <b style="">4a</b>, 3-(2-chloro­benzyl­i­­dene)-7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diaze­pin-2-one <b style="">4b</b>, 3(3-hydroxybenzylidene)-7-Chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one <b style="">4d</b>, 3-(4-N, N-dimethyl­benzylidene)-7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4] diaze­pin-2-one <b style="">4h</b> and 3(4-florobenzylidene)-7-chloro5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one <b style="">4j</b> have shown significant anticonvulsant activity as compared to reference drugs.
Description: 639-645
URI: http://hdl.handle.net/123456789/13832
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(04) [April 2012]

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