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IJC-B Vol.51B [2012] >
IJC-B Vol.51B(04) [April 2012] >


Title: An efficient total synthesis of (±)-pregabalin
Authors: Shelke, Shivaji H
Mhaske, Pravin C
Bobade, Vivek D
Keywords: γ-Amino Acid
Ruthenium Chloride
Oxidation
Reduction
Pregabalin
Issue Date: Apr-2012
Publisher: NISCAIR-CSIR, India
Abstract: The synthesis of (±)-pregabalin has been accomplished by oxidation and reduction of 2-benzyl-4-methyl pentanenitrile. The synthetic strategy involves ruthenium chloride catalyzed oxidation of the phenyl ring into carboxylic acid and reduction of nitrile into amine using sodium borohydride and nickel chloride. The approach delineated here is notable for its simplicity and efficient synthesis.
Page(s): 631-634
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.51B(04) [April 2012]

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