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|Title:||An efficient total synthesis of (±)-pregabalin|
|Authors:||Shelke, Shivaji H|
Mhaske, Pravin C
Bobade, Vivek D
|Abstract:||The synthesis of (<b style="">±</b>)-pregabalin has been accomplished by oxidation and reduction of 2-benzyl-4-methyl pentanenitrile. The synthetic strategy involves ruthenium chloride catalyzed oxidation of the phenyl ring into carboxylic acid and reduction of nitrile into amine using sodium borohydride and nickel chloride. The approach delineated here is notable for its simplicity and efficient synthesis.|
|Appears in Collections:||IJC-B Vol.51B(04) [April 2012]|
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