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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.51B [2012] >
IJC-B Vol.51B(04) [April 2012] >
| Title: | An efficient total synthesis of (±)-pregabalin |
| Authors: | Shelke, Shivaji H
Mhaske, Pravin C
Bobade, Vivek D |
| Keywords: | γ-Amino Acid
Ruthenium Chloride
Oxidation
Reduction
Pregabalin |
| Issue Date: | Apr-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The synthesis of (±)-pregabalin has been accomplished by
oxidation and reduction of 2-benzyl-4-methyl pentanenitrile. The synthetic
strategy involves ruthenium chloride catalyzed oxidation of the phenyl ring
into carboxylic acid and reduction of nitrile into amine using sodium
borohydride and nickel chloride. The approach delineated here is notable for
its simplicity and efficient synthesis. |
| Page(s): | 631-634 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.51B(04) [April 2012]
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