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Title: Effect of some pyridinium based compounds on the hydrolysis of carboxylate ester
Authors: Singh, Namrata
Ghosh, Kallol K
Keywords: Pyridinium Compounds;Nucleophilic Reactivity;Hydrolysis;Oximes;Acid Dissociation Constant
Issue Date: Apr-2012
Publisher: NISCAIR-CSIR, India
Abstract: Nucleophilic reactivity of some pyridinium based compounds towards hydrolysis of p-nitrophenyl acetate (PNPA) has been studied at pH 9.0 and temperature 27ºC. The nucleophilic reactivity of newly synthesized pyridinium compounds has been compared with commercially available pyridinium based compounds such as pralidoxime and dodecylpyridinium bromide. It has been observed that with an increase in the concentration of these compounds there is an increase in the first order rate constant of the reaction. The apparent acid dissociation constant (pKa) of some compounds have also been determined spectrophotometrically. Oximate ions released from 3-hydroxyiminomethyl-1-dodecylpyridinium bromide (3-HIDDPB) and pralidoxime have proved to be better nucleophilic agents for cleavage of carboxylate ester. Present investigation explores the structure-activity relationship of some pyridinium based compounds with same alkyl tail length.
Page(s): 611-616
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(04) [April 2012]

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