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Title: In vitro antifungal activity of ethanol fractions of Argyreia nervosa (Burm. f.) Boj. leaves
Authors: Mahule, Ajay
Rai, Pallavi
Ghorpade, Deepali S
Khadabadi, Somashekhar
Keywords: Argyreia nervosa;HPTLC;Antifungal activity;Bio-autography;Fractionation
Issue Date: Mar-2012
Publisher: NISCAIR-CSIR, India
IPC Code: Int. cl. (2011.01)- A61K 36/00, A61P 31/10
Abstract: Argyreia nervosa (Burm. f.) Boj. has been traditionally used in the treatment of skin infections. In the present study, in vitro antifungal activity of petroleum ether, benzene, ethyl acetate, chloroform fractions of ethanol extract of leaves of A. nervosa was performed. Candida albicans, Aspergillus niger, A. flavus, Trichoderma spp., Fusarium proliferatum, Microsporum spp. and Trichophyton spp. were the test organisms. The preliminary study was performed using the disc diffusion method. The ethyl acetate fraction showed significant antifungal activity as compared to other fractions. The MIC of the ethyl acetate fraction was found to be in the range of 70-80 µg/ml. The fractions were then analyzed with TLC bio-autographic analysis. The antifungal components were identified by their Rf values and these components showed positive tests for flavonoids.
Page(s): 48-54
ISSN: 0976-0512 (Online); 0976-0504 (Print)
Appears in Collections:IJNPR Vol.3(1) [March 2012]

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