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Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)] >
IJNPR Vol.3 [2012] >
IJNPR Vol.3(1) [March 2012] >
| Title: | Potentiality of aqueous leaf extract of Trichosanthes cucumerina Linn. on hair growth promotion in Wistar albino rats |
| Authors: | Sandhya, S
Chandrasekhar, J
Vinod, K R
Banji, David |
| Keywords: | Alopecia
Anagen
Bald patch
Hair follicles
Hair growth promoter
Minerals
Minoxidil
Snake gourd
Telogen
Trichosanthes cucumerina |
| Issue Date: | Mar-2012 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. cl. (2011.01)- A61K 36/42, A61K 127/00, A61P 17/14 |
| Abstract: | Trichosanthes
cucumerina Linn. (Snake gourd) is an annual climber
which is widely distributed in Asian countries. It is a rich source of
nutrition. The leaves of the plant are used by the folklore for alopecia. Hence,
in the present investigation the hair growth promoting activity was evaluated
on Wistar albino rats. The preliminary chemical screening of the aqueous
extract revealed the presence of carbohydrates, flavonoids, saponins, flavonol
glycoside and triterpenoid saponins. The animals were divided into four groups
and the control group was applied with water, standard group with 2% Minoxidil
and two test groups with 150 and 300 mg/kg of aqueous extract of T. cucumerina leaves. Qualitative and
quantitative parameters were evaluated. It was observed that the hair growth
completion, length of hair, percentage of hair follicles and diameter of bald
patch and concentration of minerals in the blood for the test animals applied
with 300 mg/kg drug was comparable with that of the animals treated with 2%
Minoxidil. This study reveals that the leaves of T. cucumerina are a potent hair growth promoter which supports the
traditional claim. |
| Page(s): | 14-19 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0976-0512 (Online); 0976-0504 (Print) |
| Source: | IJNPR Vol.3(1) [March 2012]
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