|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Journal of Scientific and Industrial Research (JSIR) >
JSIR Vol.71 [2012] >
JSIR Vol.71(04) [April 2012] >
| Title: | Development, characterization and investigation of anti-inflammatory potential of valdecoxib topical gels |
| Authors: | Raut, Sushil
Uplanchiwar, Vaibhav
Gahane, Avinash
Bhadoriya, Santosh
Patil, Shrishail
Jain, Sunil K |
| Keywords: | Cycloxygenase-2
5-Lipoxygenase
In Vitro Drug Release
Skin
Valdecoxib Gel |
| Issue Date: | Apr-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | This study presents formulation of topically effective
controlled release valdecoxib gels and evaluates potential of gels as carriers
for delivery of valdecoxib. In vitro drug release pattern for all
formulations were found to be zero order diffusion controlled release. All
formulations were compatible with skin and stable as per ICH guidelines.
Optimized valdecoxib gel significantly reduced paw oedema up to 79.51% after 6
h, whereas it was found nonsignificant to inhibit 5-lipoxygenase even though
with more doses. Valdecoxib gel with 0.5 g Carbopol is found optimized
formulation to treat local inflammation. |
| Page(s): | 273-278 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1084 (Online); 0022-4456 (Print) |
| Source: | JSIR Vol.71(04) [April 2012]
|
|
