NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Journal of Scientific and Industrial Research (JSIR) >
JSIR Vol.71 [2012] >
JSIR Vol.71(04) [April 2012] >


Title: Development, characterization and investigation of anti-inflammatory potential of valdecoxib topical gels
Authors: Raut, Sushil
Uplanchiwar, Vaibhav
Gahane, Avinash
Bhadoriya, Santosh
Patil, Shrishail
Jain, Sunil K
Keywords: Cycloxygenase-2
5-Lipoxygenase
In Vitro Drug Release
Skin
Valdecoxib Gel
Issue Date: Apr-2012
Publisher: NISCAIR-CSIR, India
Abstract: This study presents formulation of topically effective controlled release valdecoxib gels and evaluates potential of gels as carriers for delivery of valdecoxib. In vitro drug release pattern for all formulations were found to be zero order diffusion controlled release. All formulations were compatible with skin and stable as per ICH guidelines. Optimized valdecoxib gel significantly reduced paw oedema up to 79.51% after 6 h, whereas it was found nonsignificant to inhibit 5-lipoxygenase even though with more doses. Valdecoxib gel with 0.5 g Carbopol is found optimized formulation to treat local inflammation.
Page(s): 273-278
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Source:JSIR Vol.71(04) [April 2012]

Files in This Item:

File Description SizeFormat
JSIR 71(4) 273-278.pdf79.94 kBAdobe PDFView/Open
 Current Page Visits: 501 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 606510 since 06-Feb-2009  Last updated on 21-Oct-2014Webmaster: nopr@niscair.res.in