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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(03) [March 2012] >
| Title: | Effect of rosuvastatin on obesity-induced cardiac oxidative stress in Wistar rats—A preliminary study |
| Authors: | Ansari, Javed A
Bhandari, Uma
Pillai, K K
Haque, S E |
| Keywords: | Antioxidants
Apo-B
High Fat Diet
LDH
Lipid Peroxides
Obesity |
| Issue Date: | Mar-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The prevalence of obesity has been rising alarmingly and it has now become
a global concern causing an enormous economic burden on the health care system.
Obesity is generally linked to complications in lipid metabolism and oxidative
stress. The aim of the present study was to investigate the effect of
rosuvastatin (10 mg/kg, po) on obesity-induced oxidative stress in high fat-fed
Wistar rats. Oral administration of rosuvastatin (10 mg/kg) for 21 days along
with high fat diet brought about significant elevation in serum high density
lipoprotein and cardiac antioxidant enzymes levels (superoxide dismutase,
catalase, glutathione, glutathione peroxidase, glutathione peroxidase-,
glutathione reductase- and glutathione-S-transferase) while decreasing in serum lactate
dehydrogenase, apolipoprotein-B, lipids (triglycerides, total cholesterol, low density
lipoprotein-cholesterol, very low density lipoprotein-cholesterol and
atherogenic index) and cardiac thiobarbituric acid reactive substances levels.
The results were comparable with orlistat, a standard antiobesity drug. These
preliminary results for the first time demonstrate that administration of
rosuvastatin can be beneficial for the suppression of obesity-induced oxidative
stress and dyslipidemia in high fat-fed Wistar rats. |
| Page(s): | 216-222 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(03) [March 2012]
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