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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(03) [March 2012] >
| Title: | Amelioration of ionizing radiation induced lipid peroxidation in mouse liver by Moringa oleifera Lam. leaf extract |
| Authors: | Sinha, Mahuya
Das, Dipesh Kr
Datta, Sanjukta
Ghosh, Santinath
Dey, Sanjit |
| Keywords: | Gamma Radiation
Lipid Peroxidation
Liver
Reactive Oxygen Species |
| Issue Date: | Mar-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Protective effect of Moringa oleifera leaf extract (MoLE) against radiation-induced lipid
peroxidation has been investigated. Swiss albino mice, selected from an inbred
colony, were administered with MoLE (300 mg/kg body wt)
for 15 days before exposing to a single dose of 5 Gy 60Co-gamma
radiation. After treatments, animals were necropsied
at different post irradiation intervals (days 1, 7 and 15) and hepatic lipid
peroxidation and reduced glutathione (GSH) contents were estimated to observe
the relative changes due to irradiation and its possible amelioration by MoLE.
It was observed that, MoLE treatment restored GSH in liver and prevented
radiation induced augmentation in hepatic
lipid peroxidation. Phytochemical analysis showed that MoLE possess various
phytochemicals such as ascorbic acid, phenolics (catechin, epicatechin, ferulic
acid, ellagic acid, myricetin) etc., which may play the key role in prevention
of hepatic lipid peroxidation by scavenging radiation induced free radicals. |
| Page(s): | 209-215 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(03) [March 2012]
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