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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(03) [March 2012] >
| Title: | Protective effect of triphala on radiation induced acute intestinal mucosal damage in Sprague Dawley rats |
| Authors: | Yoon, Won Sup
Kim, Chul Yong
Yang, Dae Sik
Park, Young Je
Park, Won
Ahn, Yong Chan
Kim, Seok-Hyung
Kwon, Ghee Young |
| Keywords: | Epithelium
Glands
Lamina Propria
Proctitis
Radiation Protection
Triphala |
| Issue Date: | Mar-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Aim of the study was to determine protective effect of triphala on
radiation-induced rectal mucosal damage. Male Sprague Dawley rats (30) were
divided into 5 groups. Rats in group A were sham irradiated and rats in group B
underwent only irradiation. Rats in group C were administered triphala
1g/kg/day orally for 5 consecutive days before irradiation. Rats in group D and
E were administered triphala 1 and 1.5 g/kg/day orally for 10 consecutive days,
respectively. Rectal mucosal damage was induced by a single fraction of 12.5Gy
gamma irradiation (Ir-192) on 5th day. All the rats were autopsied
on 11th day and histological changes in surface epithelium, glands,
and lamina propria were assessed. Proctitis showed significant improvement in
surface epithelium (P<0.024),
glands (P<0.000) and lamina
propria (P<0.002) in group E
compared to group B. Rats in group E showed significantly less change in glands
(P<0.000) compared to rats in
group D, All histological variables (surface epithelium, P<0.001; glands, P<0.000;
lamina propria, P<0.003) compared
to rats in group C. In a Tukey-b
test, group E had a significantly recovered grade for glands (P<0.000) compared to groups B, C and
D. Results of the present study showed that high-dose triphala improved
radiation-induced damage of glands. |
| Page(s): | 195-200 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(03) [March 2012]
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