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Title: Antiviral activity of crude extracts of <i style="">Eugenia jambolana</i> Lam. against highly pathogenic avian influenza (H5N1) virus
Authors: Sood, Richa
Swarup, D
Bhatia, S
Kulkarni, D D
Dey, S
Saini, M
Dubey, S C
Keywords: Antiviral
Avian Influenza
<i style="">Eugenia jambolana</i>
<i style="">In ovo</i>
Issue Date: Mar-2012
Publisher: NISCAIR-CSIR, India
Abstract: Crude extracts of leaves and bark of <i style="">E. jambolana</i> were tested for antiviral activity against highly pathogenic avian influenza virus (H5N1) by CPE reduction assay in three different layouts to elucidate virucidal, post-exposure and pre-exposure antiviral activity of the extracts. The cold and hot aqueous extracts of bark and hot aqueous extract of leaves of <i style="">E. jambolana</i> showed significant virucidal activity (100% inhibition) which was further confirmed in virus yield reduction assay (~98 to 99% reduction) and by egg based <i style="">in ovo</i> assay. The selective index (CC<sub>50</sub>/EC<sub>50</sub>) of hot aqueous extract (248) and cold aqueous extract (43.5) of bark of <i style="">E. jambolana</i> showed their antiviral potential against H5N1 virus. The significant virucidal activity of leaves and bark of <i style="">E. jambolana</i> merits further investigation as it may provide alternative antiviral agent for managing avian influenza infections in poultry farms and potential avian-human transmission.
Description: 179-186
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.50(03) [March 2012]

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