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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(03) [March 2012] >
| Title: | Antiviral activity of crude extracts of Eugenia jambolana Lam. against highly pathogenic avian influenza (H5N1) virus |
| Authors: | Sood, Richa
Swarup, D
Bhatia, S
Kulkarni, D D
Dey, S
Saini, M
Dubey, S C |
| Keywords: | Antiviral
Avian Influenza
Eugenia jambolana
H5N1
Herbal
In ovo |
| Issue Date: | Mar-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Crude
extracts of leaves and bark of E.
jambolana were tested for antiviral activity against highly pathogenic
avian influenza virus (H5N1) by CPE reduction assay in three different layouts
to elucidate virucidal, post-exposure and pre-exposure antiviral activity of
the extracts. The cold and hot aqueous extracts of bark and hot aqueous extract
of leaves of E. jambolana showed
significant virucidal activity (100% inhibition) which was further confirmed in
virus yield reduction assay (~98 to 99% reduction) and by egg based in ovo assay. The selective index (CC50/EC50)
of hot aqueous extract (248) and cold aqueous extract (43.5) of bark of E. jambolana showed their antiviral
potential against H5N1 virus. The significant virucidal activity of leaves and
bark of E. jambolana merits further
investigation as it may provide alternative antiviral agent for managing avian
influenza infections in poultry farms and potential avian-human transmission. |
| Page(s): | 179-186 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(03) [March 2012]
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