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Title: A novel catalyst cobalt m-nitrobenzenesulfonate-catalyzed highly efficient synthesis of substituted-quinazolin-4(1H)-ones
Authors: Song, Zhiguo
Wan, Xin
Zhao, Shuang
Keywords: Benzenesulfonate
Isatoic Anhydride
One-Pot Reaction
Issue Date: Mar-2012
Publisher: NISCAIR-CSIR, India
Abstract: A highly efficient synthesis of mono- and disubstituted 2,3-dihydro-quinazolin-4(1H)-ones has been performed by the condensation of isatoic anhydride, aldehydes, and ammonium salts or amines in EtOH/H2O under reflux. A novel water-tolerant Lewis acid, cobalt m-nitrobenzenesulfonate, has been prepared and applied as a favorable catalyst in this one-pot three-component cyclocondensation reaction. The optimal amounts of catalyst and solvent are investigated. Experimental results show that only 3 mol% catalyst is enough to induce the conversion and EtOH/H2O [1/3 (v/v)] system is observed as the best choice. All the reactions are performed within a short reaction time and the catalyst is easily recovered and recycled. The structures of new compounds are characterized by IR, 1H NMR, 13C NMR, MS and elemental analysis. A mechanism to rationalize the reaction is proposed.
Page(s): 118-123
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0991 (Online); 0971-457X (Print)
Source:IJCT Vol.19(2) [March 2012]

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