Please use this identifier to cite or link to this item:
|Title:||Synthesis of 2-aryl-5-(benzofuran-2-yl)-thiazolo[3,2-<i style="">b</i>][1,2,4]triazoles using green procedures and their antibacterial activity|
Makrandi, J K
|Abstract:||3-Aryl-5-(benzofuran-2-yl)acylthio-1,2,4-triazoles <b style="">1a-h</b> have been prepared by condensation of 2-(2-bromoacetyl)benzofurans and various 3-aryl-5-mercapto-1,2,4-triazoles under thermal conditions as well as using microwave irradiations and grinding technique. 3-Aryl-5-(benzofuran-2-yl)acylthio-1,2,4-triazoles on cyclisation using polyphosphoric acid under microwave irradiations give 2-aryl-5-(benzofuran-2-yl)-thiazolo[3,2-<i style="">b</i>][1,2,4]triazoles <b style="">2a-h</b>. Preparation of compounds <b style="">1a-h</b> using grinding technique and then cyclisation to <b style="">2a-h</b> are in accordance to green procedures as these avoid use of hazardous organic solvents during the reaction as well as at its work-up stage. The antibacterial activity of these compounds has been described.|
|Appears in Collections:||IJC-B Vol.51B(03) [March 2012]|
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.