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Title: Synthesis of 2-aryl-5-(benzofuran-2-yl)-thiazolo[3,2-<i style="">b</i>][1,2,4]triazoles using green procedures and their antibacterial activity
Authors: Jakhar, Komal
Makrandi, J K
Keywords: 3-Aryl-5-mercapto-1,2,4-Triazoles
Grinding Technique
Antibacterial Activity
Issue Date: Mar-2012
Publisher: NISCAIR-CSIR, India
Abstract: 3-Aryl-5-(benzofuran-2-yl)acylthio-1,2,4-triazoles <b style="">1a-h</b> have been prepared by condensation of 2-(2-bromoacetyl)benzofurans and various 3-aryl-5-mercapto-1,2,4-triazoles under thermal conditions as well as using microwave irradiations and grinding technique. 3-Aryl-5-(benzofuran-2-yl)acylthio-1,2,4-triazoles on cyclisation using polyphosphoric acid under microwave irradia­tions give 2-aryl-5-(benzofuran-2-yl)-thiazolo[3,2-<i style="">b</i>][1,2,4]tria­zoles <b style="">2a-h</b>. Preparation of compounds <b style="">1a-h</b> using grinding technique and then cyclisation to <b style="">2a-h</b> are in accordance to green procedures as these avoid use of hazardous organic solvents during the reaction as well as at its work-up stage. The antibacterial activity of these compounds has been described.
Description: 531-536
Appears in Collections:IJC-B Vol.51B(03) [March 2012]

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