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Title: Synthesis of 2-aryl-5-(benzofuran-2-yl)-thiazolo[3,2-b][1,2,4]triazoles using green procedures and their antibacterial activity
Authors: Jakhar, Komal
Makrandi, J K
Keywords: 3-Aryl-5-mercapto-1,2,4-Triazoles
Grinding Technique
Antibacterial Activity
Issue Date: Mar-2012
Publisher: NISCAIR-CSIR, India
Abstract: 3-Aryl-5-(benzofuran-2-yl)acylthio-1,2,4-triazoles 1a-h have been prepared by condensation of 2-(2-bromoacetyl)benzofurans and various 3-aryl-5-mercapto-1,2,4-triazoles under thermal conditions as well as using microwave irradiations and grinding technique. 3-Aryl-5-(benzofuran-2-yl)acylthio-1,2,4-triazoles on cyclisation using polyphosphoric acid under microwave irradia¬≠tions give 2-aryl-5-(benzofuran-2-yl)-thiazolo[3,2-b][1,2,4]tria¬≠zoles 2a-h. Preparation of compounds 1a-h using grinding technique and then cyclisation to 2a-h are in accordance to green procedures as these avoid use of hazardous organic solvents during the reaction as well as at its work-up stage. The antibacterial activity of these compounds has been described.
Page(s): 531-536
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
Source:IJC-B Vol.51B(03) [March 2012]

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