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IJC-B Vol.51B(03) [March 2012] >

Title: Synthesis and antimicrobial activity of some new 3-chloro-6-substituted-N-(substituted 2H-[1,3]oxazino[6,5-b]quinolin-3-(4H,5aH,9aH)-yl) benzo[b]thiophene-2-carboxamides
Authors: Guruprasad, B V
Mruthyunjayaswamy, B H M
Keywords: Benzothiopene
Antimicrobial Activity
Issue Date: Mar-2012
Publisher: NISCAIR-CSIR, India
Abstract: (E)-3-Chloro-N'-((6-substituted-2-hydroxy quinolin-3-yl) methylene)-6-substituted benzo[b]thiophene-2-carbohydrazides 3a-d obtained by the reaction of 3-chloro-6-substituted benzo[b]thiophene-2-carbohydrazides 1a and 1b and 6-substituted-2-hydroxy quinoline-3-carboxaldehyde 2a and 2b, on reduction with sodium borohydride gives the respective 3-chloro-N'-((6-substituted-2-hydroxy quinolin-3-yl) methyl)-6-substituted benzo[b]thiophene-2-carbohydrazides 4a-d. These on further reaction with formalin yield 3-chloro-6-substituted-N- (6-substituted 2H-[1,3]oxazino[6,5-b]quinolin-3-(4H,5aH,9aH)-yl)benzo[b]thiophene-2-carboxamides 5a-d. The structures of all the newly synthesized compounds have been confirmed by IR, 1H NMR and mass spectral data. All these compounds have been screened for their antibacterial activity against Gram (+ve) S. aureus and B. subtilus, Gram (–ve) E. coli and K. pneumonia and antifungal activity against A. niger and C. albicans.
Page(s): 514-520
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
Source:IJC-B Vol.51B(03) [March 2012]

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