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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.51B [2012] >
IJC-B Vol.51B(03) [March 2012] >
| Title: | Synthesis and antimicrobial activity of some new 3-chloro-6-substituted-N-(substituted 2H-[1,3]oxazino[6,5-b]quinolin-3-(4H,5aH,9aH)-yl) benzo[b]thiophene-2-carboxamides |
| Authors: | Guruprasad, B V
Mruthyunjayaswamy, B H M |
| Keywords: | Benzothiopene
Quinoline
Oxazinoquinolines
Antimicrobial Activity |
| Issue Date: | Mar-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | (E)-3-Chloro-N'-((6-substituted-2-hydroxy quinolin-3-yl)
methylene)-6-substituted benzo[b]thiophene-2-carbohydrazides
3a-d obtained by the reaction of
3-chloro-6-substituted benzo[b]thiophene-2-carbohydrazides
1a and 1b and 6-substituted-2-hydroxy quinoline-3-carboxaldehyde 2a and 2b, on reduction with sodium borohydride gives the respective
3-chloro-N'-((6-substituted-2-hydroxy
quinolin-3-yl) methyl)-6-substituted benzo[b]thiophene-2-carbohydrazides
4a-d. These on further reaction with
formalin yield 3-chloro-6-substituted-N-
(6-substituted 2H-[1,3]oxazino[6,5-b]quinolin-3-(4H,5aH,9aH)-yl)benzo[b]thiophene-2-carboxamides 5a-d. The structures of all the newly synthesized compounds have
been confirmed by IR, 1H NMR and mass spectral data. All these
compounds have been screened for their antibacterial activity against Gram
(+ve) S. aureus and B. subtilus,
Gram (–ve) E. coli and K. pneumonia and antifungal activity
against A. niger
and C. albicans. |
| Page(s): | 514-520 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| Source: | IJC-B Vol.51B(03) [March 2012]
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