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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.51B [2012] >
IJC-B Vol.51B(03) [March 2012] >
| Title: | Synthesis, characterization and antimicrobial screening of novel quinoline-thiazole derivatives |
| Authors: | Desai, N C
Shihory, Niraj
Rajpara, Kiran
Dodiya, Amit |
| Keywords: | Quinoline-Thiazole
Antibacterial
Antifungal Activities |
| Issue Date: | Mar-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | 2-Chloroquinoline-3-carbaldehyde
1 reacts with 2-cyanoacetohydrazide
in ethanol to result in 1-[1-aza-2-(2-chloro(3-quinolyl))vinyl]-2-cyanoacetamide
2. Phenyl isothiocyanate added to a
stirred solution of compound 2,
sulphur and triethylamine in a mixed solvent of
dimethylformamide : ethanol to result in N-[1-aza-2-(2-chloro(3-quinolyl))vinyl](4-amino-3-phenyl-2-thioxo(1,3-thiazoline-5-yl))
carboxamide 3. Compound 3 reacts with different aldehydes in
ethanol to yield
{4-[1-aza-2-(aryl)vinyl]-3-phenyl-2-thioxo(1,3-thiazolin-5-yl)}-N-[1-aza-2-(2-chloro(3-quinolyl))vinyl]carboxamides
4a-l. These newly synthesized
compounds 4a-l have been screened
for their antibacterial activity on Escherichia coli, Pseudomonas aeruginosa,
Staphylococcus aureus and Streptococcus pyogenes, and antifungal activity on Candida albicans, Aspergillus niger
and Aspergillus clavatus. |
| Page(s): | 508-513 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| Source: | IJC-B Vol.51B(03) [March 2012]
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