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IJC-B Vol.51B(03) [March 2012] >

Title: AgOTf as an alternative catalyst for the regioselective cyclization of 2-(alkynyl)benzyl alcohols: Synthesis and biological evaluation of phthalans
Authors: Praveen, Chandrasekaran
Lyyappan, Chandran
Perumal, Paramasivan T
Girija, K
Keywords: Phthalans
Radical Scavenging
Issue Date: Mar-2012
Publisher: NISCAIR-CSIR, India
Abstract: The catalytic application of AgOTf for the regioselective cycloisomerization of 2-(alkynyl)benzyl alcohols leading to functionalized phthalans has been studied. This method offers good yield of products at short reaction time. Radical scavenging activity of all compounds has been carried out by DPPH radical scavenging method. Six compounds have been found to display comparable activity against the standard. Antibacterial activitiy of six compounds against Staphylococcus aureus and Escherichia coli has been evaluated using filter paper disc method. Three compounds have been found to exhibit antifungal activity against Candida albicans. Preliminary cytotoxic evaluation of three compounds against hepatitis-2 liver cancer cell lines has been performed by MTT assay method. The tested compounds exhibit satisfactory results of inhibition of cancer growth at different concentration.
Page(s): 498-507
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
Source:IJC-B Vol.51B(03) [March 2012]

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