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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.51B [2012] >
IJC-B Vol.51B(03) [March 2012] >
| Title: | Synthesis and anticancer activity of 3,5-diaryl-1,2,4-oxadiazole derivatives |
| Authors: | Kundu, Mrityunjoy
Singh, Jagadish
Singh, Brijesh
Ghosh, Tirtha
Maiti, B C
Maity, T K |
| Keywords: | Amidoxime
1,2,4-Oxadiazole
Acid Chloride
EAC Cells |
| Issue Date: | Mar-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | 3,5-Diaryl-1,2,4-oxadiazole derivatives are
synthesized by condensation reaction of amidoximes with aromatic acid chloride.
Amidoximes are obtained from aromatic nitriles and acid chlorides from
corresponding aromatic monocarboxylic acid derivatives. There are broad
possibilities of preparing several such compounds in this series by using
different aromatic nitriles as well as different aromatic monocarboxylic acid
derivatives. The synthesized compounds are evaluated for their anticancer
activity by using mice specific Ehrlich Ascites Carcinoma cell (EAC cells) in
Swiss albino mice model. Synthesized compounds (dose 25 mg/kg body weight) show
significant reduction of tumor cell count as well as tumor weight. Life span of
the treated mice also increases. The standard drug used for the study is
5-fluorouracil (5 mg/kg body weight). |
| Page(s): | 493-497 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| Source: | IJC-B Vol.51B(03) [March 2012]
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